方克替加氟方案序贯放化疗治疗晚期食管癌的探讨

目的对比观察局部晚期食管癌序贯放化疗与单纯放疗的疗效及毒副作用。方法71例胸上中段局部晚期食管鳞癌随机分为序贯化放疗组(A组)与单纯放疗组(B组),A组PT CF方案化疗2周期后放疗,放疗后再化疗4周期。B组单纯放疗。结果序贯放化疗组(A组)与单纯放疗组(B组)1年生存率、2年生存率、3年生存率分别为80.00%、45.70%、34.28%和61.11%、27.77%、13.89%。结论局部晚期食管癌序贯放化疗较单纯放疗的疗效提高,生存期延长,毒副作用略增加,但患者均能承受。

Cases of Locally Advanced Esophageal Carcinomas Treated with Sequential Tegafur Chemoradiotherapy

OBJECTIVE To compare the efficacy and the side effects of Sequential Chemoradiotherapy with radiotherapy in treatment of locally advanced esophageal carcinomas. METHODS 71 cases of upper thoracic and mid thoracic locally avanced esophageal carcinomas were radomizedly divided into Sequential Chemoradiotherapy arm (Arm A)and radiotherapy alone(Arm B)and Arm A patients were treated with PT CF regimen chemotherapy 2 cycles then radiotherapy was given and after that another PT CF regimen chemotherapy 4 cycles were given as well as Arm B patients were treated with radiotherapy alone. RESULT 1,2,3 year survival rates of Arm A patients and Arm B patients was 80.00E.704.28% and 61.11'.77.89%,respectively. CONCLUSIONS Compared sequential chemoradiotherapy with radiotherapy alone in treatment of locally advanced esophageal carcinomas,the efficacy was improved and the survival time was lengthened and the side effects were increased but tolerable.