| 三点法测定一室模型血管外给药的药动学参数 |
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| 引用本文： | 苏银法. 三点法测定一室模型血管外给药的药动学参数[J]. 海峡药学, 2010, 22(6): 54-55 |
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| 作者姓名： | 苏银法 |
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| 作者单位： | 浙江温州市第二人民医院药剂科,温州,325000 |
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| 摘 要： | 目的获得一室模型药物血管外给药的药动学参数;方法给予单次剂量X0,3个采样点时间为t、2t和3或4t,根据给定的药动学参数（ka、k和V/F）计算各取样点的理论血药浓度（c1、c2和c3）,推算ka、k和V/F值。结果参数推算值与给定值一致。结论三点法可以用于获取一室模型血管外给药的药动学参数。
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| 关 键 词： | 三点法 药动学 室模型 血管外给药 参数 |
Determination of the pharmacokinetic parameters of one-compartment model drug by extra-venous administration with the three-point method |
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| SU Yin-fa. Determination of the pharmacokinetic parameters of one-compartment model drug by extra-venous administration with the three-point method[J]. Strait Pharmaceutical Journal, 2010, 22(6): 54-55 |
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| Authors: | SU Yin-fa |
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| Affiliation: | SU Yin-fa(Department of Pharmacy,Second People＇s Hospital of Wenzhou,Wenzhou 325000,China) |
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| Abstract: | OBJETIVE To obtain the pharmacokinetic parameters of one-compartment model drug by extra-venous administration.METHODS The three-point method was used to calculate pharmacokinetic parameters（ka,k and V/F）by theoretic plasma concentration（c1,c2 and c3） of three sampling points（t1,t2 and t3） on provided pharmacokinetic parameters.RESULTS The calculated value of parameters was in accordance with provided.CONCLUSION The three-point method may be used to obtain the pharmacokinetic parameters of one-compartment model drug by extra-venous administration. |
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| Keywords: | three-point method pharmacokinetics compartment model extra-venous administration parameter |
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