栀子对急性胰腺炎大鼠胰腺细胞亚细胞器的保护作用

本实验利用去氧胆酸钠胰管内注射诱发大鼠急性胰腺炎，以琥珀酸脱氢酶，酸性磷酸酶，细胞２色素Ｐ４５０分别作为线粒体，溶酶体和微粒体的标志酶，检测ＡＰ时胰腺细胞亚细胞器的功能级栀子的影响，并就组织学的变化作了同步观察。

Protective Effect of Fructus Gardeniae on Pancreatic Subcellular Organs of the Acute Pancreatitis in Rats

The acute pancreatitis(AP) was induced with sodium deoxy-cholate in SD rats.Succinic dehydrogenase(SDH),acid phosphatase(ACP) and cytochrome P450 were taken as marked enzyme in estimation of mitochondria,lysosome and microsome to observe the functional and structural changes of the pancreatic subcellular organs and the protective effects of Fructus Gardeniae(FG)in acute pancreatitis in rats.The histological change was observed simultaneously.The results showed that pancreatic cellular SDH reduced significantly and the releasing rate of ACP raisedobviously in AP,in FG treated group,SDH was nearly the same as in normal,the releasing rate of ACP decreased and the content of P450 increased in the same time.Histologic observation showed that there was significant inflammatory change in pancreas and abnormal manifestation in structure of subcellular organs in AP.FG Could alleviate the lesion. These results suggested the FG has a remarkable protective effect on the function and structure of the pancreatic subcellular organs in AP.