中药热毒清对内毒素性DIC家兔血浆白细胞介素8和一氧化氮水平影响的研究

本实验采用内毒素所致家兔弥散性血管内凝血模型，测定外周血白细胞介素，亚硝酸根／硝酸根离子水平，补体Ｃ５α活性及中性粒细胞趋化指数，并观察中药热毒清注射液对上述指标的影响。结果表明：模型组血浆ＩＬ－８，ＮＯ＾－２／ＮＯ＾－３水平及Ｃ５α活性，ＰＭＮ趋化指显著升高，其升高水平和组织，器官的损害程度相一致。

Effects of Injectio Reduqing on Plasma IL-8 and Nitric oxide Levels in Rabbits with Endotoxin induced Disseminated Intravascular Coagulation

Experiments were performed for investigating the effects of Injectio Reduqing(RDQ) on plasma interleukin-8(IL-8),NO2/NO3,complement 5 a(C5a)and polymorphonuclear neufrophilic leukocyte(PMN) Chemotaxis Index(CI) in rabbits with endotoxin-induced disseminated intravascular coagulation(DIC).The results showed that plasma IL-8, NO2/NO3, C 5a and CI levels of PMN increased markedly in model group,which were confirmed pathologically with obvious damage of tissues or organs.While in RDQ group the abov-mentioned parameters and damage of tissues or organs were reduced significantly(P<0.01).The results suggested that the IL-8 and NO might be involved in pathogenesis of endotoxin-induced DIC,and RDQ could be used in preventing or treating DIC through mechanism of regulation of cytokines network.