Her-2/neu,Syndecan-1在胃癌中的表达及意义

目的：检测胃癌组织中Her 2/neu，Syndecan 1表达情况，探讨二者在胃癌发生发展及侵袭、转移中的作用。方法：应用免疫组化SP法检测112例胃癌组织及40例正常胃粘膜中Her 2/neu,Syndecan 1表达。结果：① 112例胃癌组织和40例正常胃粘膜中Her 2/neu阳性表达率分别为20.5％和5％，Syndecan 1阳性表达率分别为46.4％和100.0％。胃癌组织Her 2/neu阳性表达率显著高于正常胃粘膜阳性表达率（χ2=5.17,P＜0.05）,正常胃粘膜Syndecan 1阳性表达率显著高于胃癌组织（χ2=20.80，P＜0.01）；② 胃癌组织 Her 2/neu的表达与胃癌分化程度（χ2=4.82,P＜0.05），TNM分期（χ2=5.37,P＜0.05）、淋巴结转移多少（χ2=6.42,P＜0.05）及浆膜浸润（χ2=7.30,P＜0.01）均显著相关； ③　胃癌组织Syndecan 1的表达与胃癌分化程度、淋巴结转移呈负相关（χ2=11.83,P＜0.01和χ2=13.74,P＜0.01）；④　胃癌组织中Her 2/neu阳性表达与Syndecan 1的阴性表达显著相关(χ2=14.25,P＜0.01)。结论：①　Her 2/neu高表达显示胃癌恶性程度高、分期晚、预后不良；② Syndecan 1属保护性因素，在恶性程度高、分期晚的患者中表达降低；③ Her 2/neu阳性表达的胃癌组织中Syndecan 1的表达降低。

Effect of Her-2/neu and syndecan-1 in gastric carcinoma

To study the effect of Her 2/neu and Syndecan 1 in gastric carcinoma. Methods: The expressions of Her 2/neu and Syndecan 1 were measured by using immunohistochemistry method in 112 patients with gastric cancer and 40 healthy controls. Results： ① Her 2/neu was expressed in 20.5 % of the gastric cancer tissue and 5.0% of the healthy gastric mucosa (χ2＝5.17， P ＜ 0.05)， and Syndecan 1 was expressed in 46.4% of the gastric cancer tissue and 100% of the healthy mucosa (χ2＝20.80，　P＜ 0.01)； ② the expression of Her 2/neu was significantly correlated with the differentiation, lymph node metastasis and clinical stage (P＜0.05) and depth of invasion (P＜0.01); ③ the expression of Syndecan 1 was significantly correlated with the differentiation and the lymph node metastasis (P＜ 0.01). Conclusion： ① The expression of Her 2/neu is significantly correlated with the clinicopathological factors (P＜0.05) which suggests that Her 2/neu is a risk factor for gastric cancer;　② the expression of Syndecan 1 is significantly correlated with the differentiation and the lymph node metastasis, which suggests that Syndecan 1 is a protective factor for gastric cancer;　 ③　the expression of Her 2/neu in gastric cancer tissue is significantly correlated with that of Syndecan 1.