Exposure to misoprostol and hormones during pregnancy and risk of congenital anomalies |
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Authors: | Dal Pizzol Tatiane da Silva Sanseverino Maria Teresa Vieira Mengue Sotero Serrate |
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Affiliation: | Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Rua Vicente da Fontoura 2035, Porto Alegre, Brazil. tatiane.silva@ufrgs.br |
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Abstract: | This study evaluated the association between use of misoprostol and other drugs to induce menstruation, and congenital anomalies. A sample of 4,856 pregnant women 20 years and older were enrolled consecutively in prenatal services in the Unified National Health System, in six Brazilian State capitals. Data on socio-demographics and use of medicines were obtained using an interview from the 21st to 28th week of pregnancy. Other data, including information on delivery and diagnosis of congenital anomalies by the attending neonatal physician were obtained from patient charts. Potential confounders were adjusted by logistic regression. Use of drugs to induce menstruation was reported by 707 women (14.6%), of whom 120 (17%) reported use of misoprostol. After adjusting for the study center, a positive association was observed between misoprostol and congenital anomalies (OR = 2.64; 95% CI: 1.03-6.75); a positive association was also observed for sex hormones (OR = 2.24; 95% CI: 1.06-4.74). The results suggest that the use of misoprostol or sex hormones during pregnancy increases the risk of congenital anomalies. |
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