Expressions of cyclin D1 and p27kip1 in carcinogenesis of stomach mucosa |
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Authors: | Qunqing Liu Guiying Zhang |
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Institution: | (1) Department of Gastroenterology, Central Hospital of Xiangtan, Xiangtan, 411100, China;(2) Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha, 410000, China |
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Abstract: | Objective To evaluate the relationship between the expressions of cyclin D1 and p27kip1 in the canceration course of the stomach.
Methods The immunohistochemical staining technique (SP method) was used to detect the expressions of cyclin D1, p27kip1 in chronic superficial gastritis (CSG), chronic atrophic gastritis (CAG), intestinal metaplasia (IM), dysplasia (DYS), gastric
carcinoma (GCA) biopsy specimens.
Results The positive cyclin D1 expression rates increased with the progressing from CAG→IM→DYS→GCA respectively, and those in IM,
DYS and GCA were different from those in CSG, P < 0.05, while DYS group was indifferent from GCA group, P > 0. 05. The positive p27kip1 expression rates decreased with the mucosa progressing from CAG→IM→DYS→GCA. There was a negative correlation between the
expression cyclin D1 and p27kip1 (Y = −0.53, P = 0.000).
Conclusion Expression rates of cyclin D1 in the canceration course of the stomach mucosa trend were increased and those of p27kip1 were decreased; the abnormal expressions of them were found in the early term of the canceration course of the stomach mucosa,
and the inverse expression suggests there may be a negative feedback regulatory loop between cyclin D1 and p27kip1. |
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Keywords: | stomach neoplasms/pathology cyclin D1 protein p27kip1 immunohistochemistry carcinogenesis |
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