Biochemical characterization of the hepatic effects in mice and rats of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene, a hepatic neoplasm promoter |
| |
| Authors: | M Romano A Esteve P Coccia P Masturzo G Galliani P Ghezzi M Salmona |
| |
| Affiliation: | 1. Laboratory for Enzyme Research, Istituto di Richerche Farmacologiche “Mario Negri,” Milan, Italy;2. Department of Pharmacology, Universitat Autonoma de Barcelona, Bellaterra, Spain;3. Istituto di Chimica Organica, Università di Milano, Milan, Italy;1. Anhui Province Key Laboratory of Livestock and Poultry Product Safety Engineering, Institute of Animal Science and Veterinary Medicine, Anhui Academy of Agricultural Sciences, Hefei 230001, China;2. College of Animal Science, Anhui Science and Technology University, Chuzhou 233100, China;3. Anhui Province Key Laboratory of Animal Nutrition Regulation and Health, Chuzhou 233100, China;4. Fengyang Xiaogang Minyi Land Shares Cooperatives, Chuzhou 233100, China;1. Institute of Animal Nutrition, Northeast Agricultural University, Harbin 150030, PR China;2. College of Animal Sciences, Jilin University, Key Laboratory of Zoonosis Research, Ministry of Education, Changchun 130062, PR China;1. SIBS-UGENT-SJTU Joint Laboratory of Mycotoxin Research, CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China;2. Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China |
| |
| Abstract: | The biochemical effects on the liver of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP), a phenobarbital-like enzyme inducer, were studied in the mouse and rat. In mice a single dose of TCPOBOP (3 mg/kg, ip) caused marked and long-lasting (at least 7 days) induction of liver cytochrome P-450, 7-ethoxycoumarin-O-deethylase, and epoxide hydrolase. TCPOBOP had much less effect in rats than in mice, even at a higher dose (30 mg/kg) TCPOBOP also induced DNA synthesis in mice and rats but ornithine decarboxylase activity only in mice. In addition, in mice but not in rats, TCPOBOP increased microsomal membrane fluidity, as detected by fluorescence polarization measurements. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
