大肠正常粘膜、腺瘤及癌中微血管密度的变化

目的：探讨微血管密度（MVD）与大肠癌发生及临床病理特征的关系。方法：采用SP免疫组织化学方法显示血管内皮细胞CD34来计算MVD值，检测15例大肠正常粘膜、27例腺瘤和81例大肠癌标本的MvD值。结果：从大肠正常粘膜到腺瘤到大肠癌MVD值逐渐增高，正常粘膜及腺瘤的MVD值明显低于大肠癌（P〈0．01）。大肠癌低分化腺癌MVD值明显高于高、中分化腺癌及粘液腺癌（P〈0.01）；淋巴结转移组MVD值显著高于无淋巴结转移组（P〈0.05）；远处转移组明显高于无远处转移组（P〈0.01）；大肠癌Dukes分期D期显著高于A期和B期（P〈0．05）。结论：MVD值与大肠癌的生长及转移有关，可作为大肠癌的预后评估因子。

CHANGES OF MVD IN NORMAL MUCOSA OF LARGE INTESTINE, ADENOMA OF LARGE INTES TINE AND COLORECTAL CARCINOMA

Objective：To investigate the relationships between microvascular density （MVD） and the occurrence, clinical pathological features of colorectal carcinoma （CC）.Methods＇.SP immunohistochemical technique was used to detect MVD by displaying CD34 in vascular endothelial cell of 15 cases normal mucosa （NM）,27 cases Adenoma （Ad） and 81 cases CC.Results：The MVD gradually increased from NM to Ad to CC, and the MVD of NM and Ad were significantly lower than that of CC（P 〈 0.01）.The MVD of low differentiation CC was obviously higher than that of high, moderate differentiation adenocarcinoma and mucinous adenocarcinoma （P 〈 0.01）;the MVD was also positively correlated with lymph node metastasis,distant metastasis and Dukes stage of CC.Conclusions：MVD has related with growth and metastasis of CC,and can be acted as prognostic factor of CC.