急性脑梗死患者血中C-反应蛋白、D-二聚体水平的改变及葛根素干预研究

目的观察急性脑梗死（ACI）早期患者血中C-反应蛋白和D-二聚体含量的变化,并探讨葛根素治疗急性脑梗死的临床疗效和对C-反应蛋白和D-二聚体含量的影响。方法ACI患者64例,随机分为葛根素组（32例）（在常规治疗基础上加用葛根素）和常规治疗组（32例）。同时设立健康对照组30例。分别测定健康人和两组脑梗死患者治疗前后血中C-反应蛋白和D-二聚体含量。结果急性脑梗死早期患者血中C-反应蛋白和D-二聚体较健康人明显升高（P〈0.01）;治疗后葛根素组的D-二聚体较对照组明显降低（P〈0.05）;两组的C-反应蛋白含量差异无统计学意义（P〉0.05）;葛根素组治疗后的临床神经功能缺损评分（NIHSS,NDS）较对照组明显降低（P〈0.05）。结论急性脑梗死早期患者血中C-反应蛋白和D-二聚体含量较健康人明显升高;葛根素具有降低血中D-二聚体的作用,而对C-反应蛋白无影响;葛根素治疗急性脑梗死疗效显著。

The changes of CRP,D - D content in blood after cerebral infarction and the therapeutic effect of puerarin on them

Objective To observe the changes of C-reactive protein and D-dimer in blood after acute cerebral infarction(ACI),And to evaluate the therapeutic effect of puerarin on their changes.Methods Sixty-four cases with ACI were randomly divided into puerarin therapeutic group(Puerarin is used with general therapy) and general therapeutic group.CRP and D-D in blood after ACI were observed,while control group was set up.Results CRP and D-D content after ACI were all increased significantly(P<0.01);the changes of D-D in puerarin therapeutic group was more significantly than that in general therapeutic group(P<0.05);The changes of CRP in both were not different significantly(P>0.05);NIHSS and NDS in puerarin therapeutic group reduced more significantly than in general therapeutic group(P<0.05).Conclusion CRP and D-D content after ACI were all increased significantly;puerarin can reduce the content of D-D,but can not change the content of CRP;puerarin had significant therapeutic action on ACI.