| 颈动脉粥样硬化斑块内幽门螺杆菌-细胞毒素相关蛋白A-IgG抗体的表达与颈动脉粥样硬化性脑梗死的关系 |
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| 引用本文： | 陶珍,曲乐丰,丁素菊,管阳太,廖建胜.颈动脉粥样硬化斑块内幽门螺杆菌-细胞毒素相关蛋白A-IgG抗体的表达与颈动脉粥样硬化性脑梗死的关系[J].上海医学,2009,32(4). |
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| 作者姓名： | 陶珍 曲乐丰 丁素菊 管阳太 廖建胜 |
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| 作者单位： | 1. 第二军医大学附属长海医院神经内科,上海,200433
2. 第二军医大学附属长海医院血管外科,上海,200433 |
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| 基金项目： | 上海市浦江人才培养计划，留学回国人员科研启动基金 |
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| 摘 要： | 目的 探讨人颈动脉粥样硬化斑块内幽门螺杆菌-细胞毒素相关蛋白A(Hp-CagA)-IgG抗体的表达水平与颈动脉粥样硬化性脑梗死之间的关系.方法 选择24例因颈动脉粥样硬化狭窄行颈动脉内膜切除术且合并Hp-CagA阳性菌株感染的患者,分为有缺血性脑卒中事件组(16例)和无缺血性脑卒中事件组(8例),采用酶联免疫吸附试验检测颈动脉粥样硬化斑块内Hp-CagA-IgG抗体浓度.结果 有缺血性脑卒中事件组的颈动脉粥样硬化斑块内Hp-CagA-IgG抗体浓度显著高于无缺血性脑卒中事件组(P<0.05).结论 颈动脉粥样硬化斑块内Hp-CagA-IgG抗体表达的增高可能通过影响斑块的稳定性,导致颈动脉粥样硬化性脑梗死的发生.
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| 关 键 词： | 幽门螺杆菌-细胞毒素相关蛋白A-IgG抗体 颈动脉粥样硬化 斑块 稳定性 脑梗死 |
Association between Helicobacter pylori-cytotoxin-associated protein A-antibody IgG in carotid atherosclerotic plaques and carotid atherosclerotic cerebral infarction |
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| TAO Zhen,QU Lefeng,DING Suju,GUAN Yangtai,LIAO Jiansheng.Association between Helicobacter pylori-cytotoxin-associated protein A-antibody IgG in carotid atherosclerotic plaques and carotid atherosclerotic cerebral infarction[J].Shanghai Medical Journal,2009,32(4). |
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| Authors: | TAO Zhen QU Lefeng DING Suju GUAN Yangtai LIAO Jiansheng |
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| Institution: | TAO Zhen,QU Lefeng,DING Suju,GUAN Yangtai,LIAO Jiansheng.Department of Neurology,Changhai Hospital,Second Military Medical University,Shanghai 200433,China |
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| Abstract: | Objective To explore the association between Helicobacter pylori-cytotoxin-associated protein A-antibody IgG(Hp-CagA-IgG)in carotid atherosclerotic plaque and carotid atherosclerotic cerebral infarction.Methods A total of 24 patients with carotid atherosclerotic sclerostenosis undergoing carotid endarterectomy complicated with Hp-CagA positive strain infection were selected in this study.The patients were divided into two groups:with ischemic stroke incident(n=16)and without ischemic stroke incident(n=8).Th... |
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| Keywords: | Helicobacter pylori-cytotoxin-associated protein A-antibody IgG Carotid atherosclerotic Plaque Stability Cerebral infarction |
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