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| 海洛因成瘾者神经—免疫功能的损害 | |
| 引用本文： | 王嘉军,杨爱霞,张仲才,魏敬军,刘东亮. 海洛因成瘾者神经—免疫功能的损害[J]. 中国免疫学杂志, 2001, 17(1): 55-56 |
| 作者姓名： | 王嘉军 杨爱霞 张仲才 魏敬军 刘东亮 |
| 作者单位： | 1. 解放军473医院核医学科, 2. 解放军473医院戒毒中心, 3. 解放军473医院医务处, |
| 摘 要： | 目的：探讨海洛因成瘾者神经－免疫功能损害的原因及两系统间相互作用的关系。方法：应用ＲＩＡ法测定４５例海洛因成瘾者和４０例正常人血清中β－内啡肽（β－ＥＰ）、促肾上腺皮质激素（ＡＣＴＨ）和干扰素α（ＩＦＮα）。结果：海洛因成瘾组β－ＥＰ、ＴＦＮα含量较正常组显著降低（Ｐ〈０．０１，Ｐ〈０．００５），ＡＣＴＨ含量比正常组显著升高（Ｐ〈０．０１）。结论：①海洛因成瘾者神经系统损害的原因与外源性吗啡与脑脑内神经细胞受体结合引起内源性β－ＥＰ含量降低有密切关系；②外源性吗啡可直接与免疫细胞的码啡受体结合，抑制免疫细胞活性，造成其分泌ＩＦＮα降低，影响免疫功能；③内源性β－ＥＰ含量降低，与免疫细胞上受体结合减少，对其激活作用降低，影响ＩＦＮα分泌，减弱免疫功能。ＩＦＮα含量降低，与脑内细胞上的受体结合减少进一步抑制β－ＥＰ |
| 关 键 词： | 海洛因成瘾者 β－内啡肽 促肾上腺皮质激素 干扰素 神经－免疫功能损害 RIA法 |
| 文章编号： | 1000-484X(2001)01-0055-02 |
A preliminary study ofcorrelation between neuro and immunine function in heroin addicts |
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| Abstract. A preliminary study ofcorrelation between neuro and immunine function in heroin addicts[J]. Chinese Journal of Immunology, 2001, 17(1): 55-56 | |
| Authors: | Abstract |
| Abstract: | Objective:To investigate the injury of neuro sys tem and immune system in herion addicts.Methods:Serum content of β-EP,ACTH and IFN was detected with radioiimmunoassay in 45 heroin addicts and 40 non-heroin users as contro l.Results:Concentration of β-EP and IFN in heroin addicte d group significantly decreased (P＜0.01;P＜0.005) compared with that of the cont rol.The content of ACTH in heroin addicted group was higher than that of the con trol(P＜0.01).Conclusion:The results suggested that the function of neur o and immune system were affected by heroin ,which result in the decreasing of secretory function by some neuro-immune cells. |
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