| 弥漫性大B细胞淋巴瘤bcl-2、bcl-6、CD10蛋白表达及其在亚分类中的意义 |
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| 引用本文： | 陈愉,赵彤,蔡庆发,吴炳绪,陈美燕.弥漫性大B细胞淋巴瘤bcl-2、bcl-6、CD10蛋白表达及其在亚分类中的意义[J].肿瘤防治研究,2008,35(8):563-565. |
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| 作者姓名： | 陈愉 赵彤 蔡庆发 吴炳绪 陈美燕 |
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| 作者单位： | 福州总医院九五临床部病理科; 南方医科大学附属南方医院病理科; 莆田学院附属医院病理科; |
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| 摘 要： | 目的探讨bcl-2、bcl-6、CD10在弥漫性大B细胞淋巴瘤(diffuse large B-cell lymphoma,DL-BCL)中的表达及意义。方法应用免疫组织化学SP法,检测60例弥漫性大B细胞淋巴瘤标本中bcl-2、bcl-6、CD10蛋白的表达水平。结果bcl-2、bcl-6、CD10在60例弥漫性大B细胞淋巴瘤中的表达率分别为55.0%(33/60)、48.3%(29/60)、46.7%(28/60),其中CD10(+)/bcl-6(+)15例,25%;CD10(+)/bcl-6(-)13例,21.7%;CD10(-)/bcl-6(+)14例,23.3%;CD10(-)/bcl-6(-)18例,30%。CD10(+)/bcl-6(+)与CD10(-)/bcl-6(-)中bcl-2的表达差异具有统计学意义。结论bcl-2有望成为DLBCL亚分类的指标。
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| 关 键 词： | bcl-2 bcl-6 CD10 弥漫性大B细胞淋巴瘤 免疫组织化学 |
| 收稿时间： | 2007-8-29 |
| 修稿时间： | 2007-11-12 |
Expression of bcl-2,bcl-6,CD10 Protein and Their Significance in Subgroups of Diffuse Large B-cell Lymphoma |
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| CHEN Yu,ZHAO Tong,CAI Qing-fa,WU Bing-xu,CHEN Mei-yan.Expression of bcl-2,bcl-6,CD10 Protein and Their Significance in Subgroups of Diffuse Large B-cell Lymphoma[J].Cancer Research on Prevention and Treatment,2008,35(8):563-565. |
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| Authors: | CHEN Yu ZHAO Tong CAI Qing-fa WU Bing-xu CHEN Mei-yan |
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| Institution: | 1.Department of Pathology; The 95th Military Hospital; Putian 351100; China; 2.Department of Pathology; Nanfang Medical University; 3.Department of Pathology; Affiliated Hospital of Putian University |
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| Abstract: | Objective To investigate the expression of bcl-2,bcl-6,CD10 protein and their significance in subgroups of diffuse large B-cell lymphoma.Methods Immunohistochemistry technique(SP method) was used to assess the expression levels of bcl-2,bcl-6,CD10 protein in 60 cases of diffuse large B-cell lymphoma.Results Expression of bcl-2,bcl-6 and CD10 protein was found in 33/60(55.0%),29/60(48.3%),28/60(46.7%) cases,respectively.The CD10/bcl-6 patterns were as follows: CD10(+)/bcl-6(+) 15 cases,25%;CD10(+)/bcl-6(-)13... |
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| Keywords: | bcl-2 bcl-6 CD10 |
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