| 奥沙普秦凝胶基质的筛选研究 |
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| 引用本文： | 郭宏,刘志东,杨星钢,潘卫三.奥沙普秦凝胶基质的筛选研究[J].中国药房,2005,16(21):1622-1624. |
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| 作者姓名： | 郭宏 刘志东 杨星钢 潘卫三 |
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| 作者单位： | 1. 沈阳药科大学药学院,沈阳市,110016;佳木斯大学化学与药学院,佳木斯市,154007
2. 沈阳药科大学药学院,沈阳市,110016 |
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| 摘 要： | 目的:考察不同型号卡波姆对奥沙普秦凝胶体外经皮渗透性的影响,筛选奥沙普秦凝胶的基质。方法:采用Franz扩散池, 以大鼠离体皮肤为屏障,进行体外渗透性实验。结果:以卡波姆940为基质的奥沙普秦凝胶体外渗透系数为22．77／μg／(cm2·h),其 体外渗透性最佳。结论:本文筛选的凝胶基质,可为其生产提供参考依据。
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| 关 键 词： | 奥沙普秦 凝胶 渗透系数 透皮吸收 |
| 文章编号： | 1001-0408（2005）21-1622-03 |
| 收稿时间： | 2005-03-11 |
| 修稿时间： | 2005-04-22 |
Study on Base Material Optimization of Oxaprozin Gel |
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| GUO Hong,LIU Zhidong,YANG Xinggang,PAN Weisan.Study on Base Material Optimization of Oxaprozin Gel[J].China Pharmacy,2005,16(21):1622-1624. |
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| Authors: | GUO Hong LIU Zhidong YANG Xinggang PAN Weisan |
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| Abstract: | OBJECTIVE: To observe the effects of different types of carbomers on percutaneous permeability of oxaprozin gels in vitro and to opitmize the formulation of oxaprozin gel. METHODS: The permeability test in vitro was carried out by using Franz diffusion cell with rats' ex vivo skin as barrier. RESULTS: The ex vivo permeability of oxaprozin gel was the best when the carbomer 940 used as its base material with its ex vivo permeability coefficient at 22.77μg/ (cm2·h) . CONCLUSION : The optimized gel base material can act as bases for the production of oxaprozin gel. |
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| Keywords: | Oxaprozin Gels Permeability coefficient Transdermal absorption |
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