泵基础量转换为甘精胰岛素的剂量换算关系及血糖波动程度比较

目的 探讨胰岛素泵治疗使血糖相对平稳后转换为胰岛素多点皮下注射治疗,比较胰岛素泵治疗时的基础量和甘精胰岛索之间的剂量关系及转换前后整体血糖的波动情况.方法 将2006年3月至2008年4月收治的102例2型糖尿病患者应用胰岛素泵治疗使血糖平稳后,改为甘精胰岛素联合门冬胰岛素多点皮下注射治疗,在空腹血糖相对稳定的前提下,观察胰岛素泵基础用量及甘精胰岛素用量,同时比较转换前后全日血糖的波动情况.结果 胰岛素泵的基础量为(0.30±0.11)U/(kg·d),甘精胰岛素的用量为(0.28±0.09)U/(kg·d),两者比较差异无统计学意义;胰岛素泵治疗达标时的日平均血糖为(7.94±1.32)mmol/L,胰岛素多点皮下注射治疗达标时的日平均血糖为(7.49±1.34)mmol/L,两者的日平均血糖分别大于3倍的样本标准差.结论 甘精胰岛素可以起到类似于胰岛索泵基础量模式的作用.

Comparison of insulin dose and blood glucose fluctuation between glargine-based multiple daily insulin injections and continuous subcutaneous insulin infusion

Objective To compare the doses of shrsine with the basal insulin of continuous subcutaneous insulin infusion(CSII) and the fluctuation of blood glucose (BG)in patients with diabetes mellitus from CSII to glargine-based multiple dally insulin injections therapy.Methods One hundred and two type 2 diabetic patients achieved ideal glycemia control with CSII,then transferred to slarsine-based multiple daily insulin injections therapy.The doses of glargine with the basal insulin of insulin pump and the flucmarion of BG were compared in type 2 diabetic patients from CSII to shrgine-based multiple daily insulin injecfions therapy.Results When the fasting BG achieved an ideal level,the basal insulin doses of CSII were(0.30±0.11)U/(kg·d),and the doses of ghrgine insulin were(0.28±0.09)U/(kg·d).However,the difference between the two methods was no statistically significant.The mean level of BG of CSII and multipie daily insulin injections was(7.94±1.32)mmol/L and(7.49±1.34)mmol/L respectively,the mean BG levels of two methods were more than their three times sample standard deviation.Conclusion Glargine insulin Callphya similax role in the basal insulin of CSII.