米氮平联合重复经颅磁刺激治疗老年焦虑症伴睡眠障碍的临床效果分析

目的 探讨米氮平联合重复经颅磁刺激治疗老年焦虑症伴睡眠障碍的临床效果。方法 选择2018 年1 月至2019 年12 月在我院诊断治疗的老年焦虑症伴睡眠障碍患者100 例为研究对象，随机分为观察组与对照组各50 例。两组均给予米氮平治疗，观察组在此基础上予重复经颅磁刺激治疗。比较两组治疗前后HAMA 评分、PSQI 评分以及临床疗效。结果 （1）治疗后，观察组HAMA 评分（13.0±2.5）分，对照组（18.1±1.8）分，两组均显著下降，与治疗前比较，差异有统计学意义（P＜0.05）；HAMA 评分治疗后观察组较对照组低，差异有统计学意义（P＜0.05）。（2）治疗后，观察组PSQI 评分（6.2±1.1）分，对照组（10.7±1.4）分，两组均显著下降，低于治疗前，差异有统计学意义（P＜0.05）；观察组治疗后PSQI 评分低于对照组，差异有统计学意义（P＜0.05）。（3）临床痊愈率观察组32.0%，对照组为10.0%，观察组高于对照组，差异有统计学意义（P＜0.05）。观察组总有效率100.0%，显著高于对照组，差异有统计学意义（P＜0.05）。结论 米氮平联合重复经颅磁刺激治疗老年焦虑症伴睡眠障碍可显著改善患者焦虑症状及睡眠障碍情况。

Analysis on the clinical efficacy of mirtazapine combined with repetitive transcranial magnetic stimulation in the treatment of senile anxiety disorder complicated with sleep disorder

Objective To investigate the clinical efficacy of mirtazapine combined with repetitive transcranial magnetic stimulation(rTMS) in the treatment of senile anxiety complicated with sleep disorder.Methods A total of 100 senile patients with anxiety and sleep disorder diagnosed and treated in our hospital from January 2018 to December 2019 were selected as the objects,and they were randomly divided into the observation group(n=50) and the control group (n=50).Both groups were treated with mirtazapine,while the observation group was treated with rTMS based on the control group.HAMA score,PSQI score and clinical efficacy were compared between the two groups before and after treatment.Results (1)After treatment,the HAMA score of the observation group was (13.0±2.5) points,and the control group was(18.1±1.8) points.HAMA scores of both groups were decreased significantly,and the difference was statistically significant compared with that before treatment(P<0.05).After treatment,HAMA score of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).(2)After treatment,the PSQI score of the observation group was(6.2±1.1) points and the control group was(10.7±1.4) points,PSQI scores of both groups were significantly lower than those before treatment,and the differences were statistically significant(P<0.05).After treatment,the PSQI score of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).(3) The clinical recovery rate of the observation group was 32.0%,which was higher than 10.0% of the control group,and the difference was statistically significant(P<0.05).The total effective rate of the observation group was 100.0%,which was significantly higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion Mirtazapine combined with rTMS can significantly relieve anxiety and sleep disorders in senile patients.