铁及氧化应激在多发性硬化中的作用机制及其MRI研究进展

多发性硬化(multiple sclerosis,MS)是中枢神经系统最常见的一种炎性脱髓鞘疾病,其发病机制迄今不明。近年来研究表明铁和氧化应激均参与到MS的发病机制中,但其具体的时间空间动态变化规律尚未完全被阐明。因此,借助多参数MRI进行在体无创性定量评估MS病灶内的铁及氧化应激水平,对揭示MS各期不同病理特征具有重要意义。作者就铁及氧化应激在多发性硬化中的潜在致病机制和相应MRI研究进展进行综述。

The pathogenesis of iron and oxidative stress in multiple sclerosis and advances in MRI

Multiple sclerosis(MS)is the most common inflammatory demyelinating disease in the central nervous system,and its pathogenesis is still unknown.In recent years,studies have shown that iron and oxidative stress are involved in the pathogenesis of MS,but the specific temporal and spatial dynamic changes have not been fully clarified.Therefore,the non-invasive quantitative evaluation of iron and oxidative stress in MS lesions with multi-parameter MRI is of great significance to reveal the different pathological characteristics of MS in different stages.This article reviews the potential pathogenic mechanism of iron and oxidative stress in multiple sclerosis and the corresponding research progress of MRI.