射频消融术对不同起源频发室性期前收缩患者左心房功能、结构及血浆脑钠肽浓度的影响

目的 分析射频消融术(radiofrequency catheter ablation,RFCA)对不同起源频发室性期前收缩患者左心房功能、结构及血浆脑钠肽(brain natriuretic peptide,BNP)浓度的影响.方法 收集2016年1月至2019年12月宣城市中心医院与南京市第一医院93例行RFCA治...

Effects of radiofrequency catheter ablation on left atrial function,structure and plasma concentration of brain natriuretic peptide in patients with frequent ventricular premature contractions of different origins

Objectives To analyze the effect of radiofrequency catheter ablation(RFCA)on left atrial function,structure and plasma concentration of brain natriuretic peptide(BNP)in patients with frequent premature ventricularcontractions of different origins.Methods Totally 93 patients with frequent premature ventricular contractions treatedby RFCA were selected in Xuancheng Central Hospital and Nanjing First Hospital from January 2016 to December 2019.According to the different origins of premature ventricular contractions,93 patients were divided into left ventriculargroup(n=30)and right ventricular group(n=63),and 40 healthy persons in the same period were selected as controlgroup.The function and structure of left atrium in the three groups were measured,and the changes of plasma concen-tration of BNP and left atrium function and structure before and after operation were compared.Results Compared with control group,left ventricular ejection fraction(LVEF),left atrial ejection fraction(LAEF)and left ventricularstroke volume(LVSV)in left ventricular group and right ventricular group significantly decreased;while left ventriculardiameter(LVD),left atrial diameter(LAD),left ventricular posterior wall diameter(LVPWD),left ventricular enddiastolic diameter(LVEDD),left ventricular end systolic diameter(LVESD),left atrial strain rate during left atrialsystole(LASRa)significantly increased(P<0.05).LAEF of right ventricular group was significantly higher than that ofleft ventricular group at 4 weeks postoperatively,LAD of right ventricular group at 1 week and 4 weeks postoperativelywere significantly lower than those of left ventricular group,and the left atrial strain rate(LASR),LASRa and left atrialstrain rate during left ventricular systole(LASRs)of right ventricular group significantly improved compared with thoseof left ventricular group(P<0.05).Compared with control group,plasma concentration of BNP in left and right ventriculargroups were significantly higher(P<0.05)before operation.Plasma concentrations of BNP in left and right ventriculargroups at 4 weeks after operation were significantly lower than those before operation(P<0.05).Plasma concentrationof BNP in right ventricular group was significantly lower than that in left ventricular group at 4 weeks after operation(P<0.05).Conclusions Plasma concentration of BNP in patients with frequent ventricular premature contractions ofdifferent origins increases,and the left atrium function and structure are damaged.Plasma concentration of BNP,theleft atrium function and structure in patients with right ventricular origin are significantly better than those in patientswith left ventricular origin patients after RFCA.