硫必利与氟哌啶醇治疗青少年抽动障碍的临床效果比较 |
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基金项目: | 浙江省医学会临床科研基金项目(2018ZYC-A128) |
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摘 要: | 目的 比较硫必利与氟哌啶醇治疗青少年抽动障碍的临床效果。方法 采用随机法选取我院2018年10月至2019年11月收治的抽动障碍患者为92例研究对象,分为对照组、观察组,每组46例。分别采用药物氟哌啶醇、硫必利治疗,比较两组临床效果、抽动严重程度评分、神经递质指标,包括去甲肾上腺素(NE)、多巴胺(DA)、5-羟色胺(5-HT)以及不良反应情况。结果 观察组治疗总有效率为97.82%,显著高于对照组86.96%,差异有统计学意义(P0.05);治疗前,两组YGTSS评分比较,差异无统计学意义(P0.05)。治疗后,观察组YGTSS评分为(24.89±3.42)分低于对照组(26.71±3.56)分,差异有统计学意义(P0.05);观察组、对照组治疗前后YGTSS评分比较,差异有统计学意义(P0.05)。治疗后,观察组NE水平为(36.54±10.03)ng/mL,显著高于对照组(32.22±9.01)ng/mL,DA、5-HT水平分别为(13.11±3.81)ng/mL、(56.71±11.58)ng/mL,显著低于对照组(15.17±4.35)ng/mL、(63.51±12.55)ng/mL,差异有统计学意义(P0.05);观察组、对照组治疗前后NE、DA、5-HT水平比较,差异有统计学意义(P0.05)。观察组不良反应发生率为6.52%,显著低于对照组19.57%,两组差异有统计学意义(P0.05)。结论 硫必利治疗抽动障碍疾病能够提高患者的临床效果,减轻受损程度,能够调控垂体激素分泌,调节自主神经功能,改善患者的临床症状,降低不良反应,值得推广。
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关 键 词: | 青少年 抽动障碍 硫必利 氟哌啶醇 神经递质 |
Comparison clinical efficacy of tiapride and haloperidol in the treatment of tic disorder in adolescents |
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Abstract: | Objective To compare the clinical efficacy of tiapride and haloperidol in the treatment of tic disorder in adolescents.Methods A total of 92 patients with tic disorder admitted to and treated in our hospital from October 2018 to November 2019 were randomly selected as the research objects.They were divided into the control group (n=46) and the observation group (n=46).Patients in the control group were treated with haloperidol,and those in the observation group were treated with tiapride.The clinical efficacy,tic severity score,neurotransmitter indicesincluding noradrenaline(NE),dopamine (DA),5-hydroxytryptamine (5-HT)] and adverse reactions (ARs) were compared between the two groups.Results The total effective rate of the observation group was 97.82%,which was significantly higher than 86.96% of the control group,with statistically significant difference (P<0.05).Before treatment,there was no significant difference in the scores of Yale global tic severity scale (YGTSS) between the two groups (P>0.05).After treatment,the YGTSS score of the observation group was (24.89±3.42),which was lower than (26.71±3.56) in the control group,with statistically significant difference (P<0.05).Before and after treatment,there was statistically significant difference in YGTSS scores in the observation group and the control group(P<0.05).After treatment,the NE level in the observation group was(36.54±10.03) ng/mL,which was significantly higher than (32.22±9.01) ng/mL in the control group.The levels of DA and 5-HT were (13.11±3.81) ng/mL and (56.71±11.58) ng/mL,respectively,which were significantly lower than (15.17±4.35) ng/mL and (63.51±12.55) ng/mL in the control group,with statistically significant differences (P<0.05).Before and after treatment,the levels of NE,DA and 5-HT in the observation group and the control group were significantly different (P<0.05).The incidence of ARs in the observation group was 6.52%,which was significantly lower than 19.57% in the control group,with statistically significant difference (P<0.05).Conclusion In the treatment of tic disorder,tiapride can improve the clinical efficacy of patients,reduce the degree of damage,regulate pituitary hormone secretion,regulate autonomic neurological function,improve the clinical therapy effects of patients and reduce ARs.Therefore,it is worthy of promotion. |
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Keywords: | Adolescents Tic disorder Tiapride Haloperidol Neurotransmitter indeces |
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