试管婴儿双胎妊娠的母婴临床结局研究

目的 探讨试管婴儿双胎与单胎妊娠的母婴临床特征及妊娠结局。方法 回顾性分析2017 年1 月至2019年12 月在我院产科住院分娩的试管婴儿病例620 例,其中双胎妊娠195 例作为研究组,单胎妊娠病例425 例作为对照组,对其分娩前及分娩后临床资料及数据等进行研究分析。结果 研究组的住院天数（12.77±2.96）d、妊娠高血压疾病（19.00%）、早产（60.00%）、低出生体重儿（28.20%）均高于对照组的（9.92±1.26）d、11.30%、15.80%、5.60%,差异均有统计学意义（P＜0.05）。研究组剖宫产分娩率（99.00%）,产后出血例数（25.60%）,宫腔球囊填塞止血例数（29.20%）均高于对照组的66.60%,17.60%,12.00%,差异均有统计学意义（P＜0.05）。但研究组的高龄妊娠例数（20.50%）和胎膜早破例数（12.30%）均低于对照组的29.90%、16.90%,差异均有统计学意义（P＜0.05）。结论 试管妊娠双胎与单胎相比,其母婴并发症及合并症明显多于单胎,故对于不孕不育的患者在移植过程中,对于胚胎移植数目需严格按照指南进行,加强产前检查,监测孕期胎儿体重情况,积极处理,避免不良结局的发生。

Study on the mother and infant clinical outcome of twin pregnancy in test-tube baby

Objective To explore the mother and infant clinical characteristics and pregnancy outcome of test-tube twin pregnancy and singleton pregnancy.Methods A total of 620 cases of test-tube babies who were hospitalized and gave birth in the Department of Obstetrics in our hospital from January 2017 to December 2019 were retrospectively analyzed.Among them,195 cases of twin pregnancy were used as the study group,and 425 cases of singleton pregnancy were used as the control group.The clinical data before and after delivery were studied and analyzed.Results The length of stays(12.77±2.96)days,the number of cases of pregnancy-induced hypertension (19.00%),the number of preterm births (60.00%),and the number of low birth weight infants(28.20%) in the study group were all higher than the length of stays (9.92±1.26)days,the number of cases of pregnancy-induced hypertension (11.30%),the number of premature births(15.80%),and the number of low birth weight infants(5.60%) in the control group,and the differences between the two groups were statistically significant(P<0.05).The delivery rate of Cesarean section (99.00%),the number of cases of postpartum hemorrhage (25.60%),the number of cases of uterine balloon tamponade hemostasis (29.20%) in the study group were higher than the delivery rate of Cesarean section (66.60%),and the number of cases of postpartum hemorrhage(17.60%),the number of cases of uterine balloon tamponade hemostasis(12.00%) in the control group,and the differences between the two groups were statistically significant (P<0.05).However,the number of cases of elderly pregnan group (20.50%) and premature rupture of membranes (12.30%) in the study group were lower than those in the control group(29.90%and 16.90%),and the differences between the two groups was statistically significant(P<0.05).Conclusion Compared with singleton pregnancy,test-tube twins have significantly more mother and infant complications and concurrent disorders than singleton pregnancy.Therefore,in the process of transplantation for infertile patients,the number of embryo transfers must be carried out in strict accordance with the guidelines,prenatal inspections should be strengthened,and the fetal weight during pregnancy should be monitored.Measures should be carried out in a timely manner to avoid adverse outcomes.