PI3K-Akt-mTOR通路在慢阻肺发病机制中的研究进展

慢性阻塞性肺疾病(简称慢阻肺)为人体呼吸机制病症内的一种气道炎症性病症,具备一定的常见性,其发病率和病死率均较高,是一个重要的全球性公共卫生问题。通过相关探究发现,磷脂酰肌醇3激酶/蛋白激酶B/雷帕霉素靶蛋白(P13K-Akt-mTOR)信号通路,参与细胞的多个环节,如增殖、凋亡、自噬,是经典的细胞组织内的信号通路。影响各个不同系统疾病的预后及转归。国内外的专家学者经过大量研究对PI3K-Akt-mTOR信号传导通路在肿瘤细胞增殖、自噬、凋亡过程的研究中已取得一定的程度的进展,但在PI3K-Akt-mTOR信号传导通路与慢性阻塞性肺疾病的相互关系的研究领域中仍存涉足较少。本文就近年来PI3K-Akt-mTOR通路与慢阻肺关系的研究进展做一综述。

Research progress of PI3K-Akt-mTOR pathway in the pathogenesis of chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (abbreviated as COPD),which is an inflammatory disease of the airway in the respiratory mechanism of the human body,has a certain commonness,and its morbidity and fatality rate are both high.It is an important global public health issue.Through related investigations,it is found that the phosphatidylinositol 3-kinase/protein kinase B/target of rapamycin (P13K-Akt-mTOR) signaling pathway is involved in many aspects of the cell,such as proliferation,apoptosis,and autophagy,which is a classic signaling pathway in cell tissue and affects the prognosis and outcome of various diseases in different systems.Experts and scholars at home and abroad have made a certain degree of progress in the study of the PI3K-Akt-mTOR signal transduction pathway in the process of tumor cell proliferation,autophagy,and apoptosis after a large number of studies.However,there is still little involvement in the research field of the relationship between PI3K-Akt-mTOR signaling pathway and chronic obstructive pulmonary disease.This article reviews the research progress of the relationship between PI3K-Akt-mTOR pathway and COPD in recent years.