孟鲁司特钠联合布地奈德治疗老年支气管哮喘的疗效

目的 探讨孟鲁司特钠联合布地奈德治疗老年支气管哮喘的临床疗效。方法 选择我院2017年5月至2020年5月收治的老年支气管哮喘96例进行研究,以随机数字表法分为两组,每组各48例。对照组用布地奈德治疗,观察组用孟鲁司特钠联合布地奈德治疗。评价两组临床疗效,检测治疗前后肺功能指标与血气分析指标,其中肺功能指标包括第1秒用力呼气容积(FEV1)与呼气峰流速(PEF),血气分析指标包括血氧分压(PaO2)、血二氧化碳分压(PaCO2),并对两组指标比较分析。结果 观察组总有效率为95.83%,高于对照组81.25%,差异有统计学意义(P0.05);治疗前两组肺功能指标与血气分析指标比较,差异无统计学意义(P0.05),治疗后观察组FEV1、PEF、PaO2为(2.08±0.74)L、(1.78±0.46)L/s、(80.05±10.25)mmHg,高于对照组的(1.65±0.56)L、(1.45±0.35)L/s、(74.23±10.02)mmHg,差异有统计学意义(P0.05),观察组PaCO2为(40.03±2.78)mmHg,低于对照组的(44.09±3.26)mm Hg,差异有统计学意义(P0.05)。结论 老年支气管哮喘应用孟鲁司特钠联合布地奈德治疗,可提高疗效,更好地改善肺功能与血气分析指标,值得应用。

Therapeutic efficacy of montelukast sodium combined with budesonide in the treatment of senile bronchial asthma

Objective To investigate the clinical efficacy of montelukast sodium combined with budesonide in the treatment of senile bronchial asthma.Methods A total of 96 senile patients with bronchial asthma admitted to and treated in our hospital from May 2017 to May 2020 were selected for research,and they were divided into the control group(n=48)and the observation group (n=48) according to the random number table method.The control group was treated with budesonide,while the observation group was treated with montelukast sodium combined with budesonide.The clinical efficacy of the two groups was evaluated,and the indices of pulmonary function and blood gas analysis were detected before and after treatment.The indices of pulmonary function included the forced expiratory volume in the first second(FEV1) and the peak expiratory flow rate (PEF).And the indices of blood gas analysis included the partial pressure of blood oxygen(PaO2) and the partial pressure of blood carbon dioxide(PaCO2).The two groups of indices were compared and analyzed.Results The total effective rate was 95.83% in the observation group,which was higher than that of control group(81.25%),with statistically significant difference (P<0.05).Before treatment,there were no statistically significant differences in the indices of pulmonary function and blood gas analysis between the two groups (P>0.05).After treatment,FEV1,PEF and PaO2 in the observation group were (2.08±0.74)L,(1.78±0.46)L/s and (80.05±10.25)mmHg,which were higher than those in the control group(1.65±0.56)L,(1.45±0.35)L/s and(74.23±10.02) mmHg,with statistically significant difference(P<0.05),PaCO2 in the observation group were(40.03±2.78)mmHg,which were lower than those in the control gro(44.09±3.26) mmHg,respectively,with statistically significant differences(P<0.05).Conclusion The application of montelukast sodium combined with budesonide in the treatment of senile bronchial asthma can increase the therapeutic efficacy,better improve the indices of pulmonary function and blood gas analysis.Therefore,it is worthy of application.