嗜酸性粒细胞增多性皮炎16例回顾性分析

目的:探讨嗜酸性粒细胞增多性皮炎(HED)的临床特点、治疗方案及后期转归情况,为临床诊断和治疗提供参考.方法:对2014—2019年16例HED住院患者临床资料及实验室检查进行回顾性分析.结果:16例患者中,男女发病比为7:1,皮疹主要表现为红斑、丘疹(约70％),多全身泛发,伴有明显瘙痒.误诊10例(62.50％)....

Retrospective analysis of 16 cases of hypereosinophilic dermatitis

Objective：To explore the clinical features, treatment options and later outcomes of hypereosinophilic dermatitis(HED). Methods:A retrospective clinical data was analyzed for 16 HED inpatients from 2014 to 2019. Results:The ratio of male to female was 7 ∶ 1. The rash was mainly manifested as generalized itchy erythema and papules (about 70%). Among the 16 patients, 10 patients (62.50%) were misdiagnosed. Treatment with glucocorticoids was effective. Tripterygium wilfordii, thalidomide, compound glycyrrhizin and PUVA phototherapy could alleviate clinical symptoms. Conclusions:HED tends to occur in male patients. Misdiagnosis and missed diagnosis of this disease are not uncommon. Low and medium-dose glucocorticoids alone or in combination with immunosuppressive agents are effective to treat patients with HED. Compound licorice preparations or methotrexate and cyclosporine can be considered for HED patients with contraindications of glucocorticoids or poor response to glucocorticoids.