偏瘫复康颗粒对脑缺血再灌注损伤的保护作用

目的 :探讨大鼠脑缺血再灌注损伤后偏瘫复康颗粒的保护作用及其可能机制。方法 :采用线栓法制备大鼠大脑中动脉缺血再灌注模型。观察组织病理学、脑组织含水量、血浆ET和CGRP含量 ,血清SOD和NO含量的变化。结果 :与模型组比较 ,偏瘫复康颗粒对手术侧脑组织含水量有明显降低作用 ,对血清SOD、血浆CGRP具有显著升高作用 (P <0 .0 1) ,对血清NO、血浆ET含量具有显著降低作用。结论 :偏瘫复康颗粒对脑缺血再灌注损伤所具有的保护作用可能和参与调节ET、CGRP、NO、SOD等因素有关。

Protective Effect of Pian Tan Fu Kang Granule on Cerebral Ischemia and Reperfusion Injury in Rats

To study the protective effect and the possible mechanism of Pian Tan Fu Kang Capsule (PTFK) on injury induced by cerebral ischemia and reperfusion in rats, Rats were exposed to right middle cerebral artery occlusion for 40 min and reperfusion for 24 hours. Pathological changes, content of water on brain tissue, content changes of endothelin (ET) and calcitonin gene related peptide (CGRP) on plasma, and content changes of superoxide dismutase (SOD) and nitric oxide (NO) in serum were observed. Results showed PTFK could significantly alleviate the pathological damage and reduce content of water on brain tissue compared with injury side of brain, it could obviously increase contents of SOD in serum and CGRP on plasma, and decrease contents of NO in serum and ET in serum and ET in plasma compared with control group. The results indicate the protective effect of PTFK on cerebral ischemia and reperfusion injury might be relation to regulating balances of ET, CGRP, SOD and NO in plasma or serum.