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睾丸源性生殖障碍综合征研究进展
引用本文:徐哲明.睾丸源性生殖障碍综合征研究进展[J].中华男科学杂志,2010,16(12).
作者姓名:徐哲明
摘    要:睾丸源性生殖障碍综合征(TDS)是近10年来男性不育领域研究的热点。环境内分泌干扰因子作用于睾丸Leydig细胞和/或Sertoli细胞致使睾丸发育异常,从而导致TDS症状的出现是被广泛接受的发病机制。分子生物学研究提示类胰岛素样因子3(INSL-3)、雄激素受体(AR)、P27kip蛋白、WT-1基因及副中肾管抑制物(M IS)等可能与TDS的发病有关,本文对TDS的病因、机制及研究进展等进行了综述。

关 键 词:睾丸源性生殖障碍综合征  隐睾  尿道下裂  少精子症  睾丸癌

Testicular dysgenesis syndrome:An update
XU Zhe-ming.Testicular dysgenesis syndrome:An update[J].National Journal of Andrology,2010,16(12).
Authors:XU Zhe-ming
Abstract:Researches on the testicular dysgenesis syndrome(TDS) have flourished in the recent decade,and a widely accepted view on its pathogenesis is that environmental endocrine disrupting chemicals(EDCs) act on Leydig cells and/or testicular Sertoli cells,resulting in abnormal development of the testis and leading to the symptoms of TDS.Molecular biological studies suggest a correlation of TDS etiology with insulin-like factor 3(INSL-3),androgen receptor(AR),P27kip,WT-1 and Müllerian inhibiting substance(MIS).This review focuses on the progress in current researches on the etiology and mechanism of TDS.
Keywords:testicular dysgenesis syndrome  cryptorchidism  hypospadia  oligospermia  testicular cancer
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