| 睾酮经皮渗透系数与介质溶解度参数的关系 |
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| 引用本文： | 胡富强,梁文权.睾酮经皮渗透系数与介质溶解度参数的关系[J].中国医学科学院学报,1997,19(2):127-130. |
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| 作者姓名： | 胡富强 梁文权 |
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| 作者单位： | 中国医学科学院浙江分院!杭州，310031，中国医学科学院浙江分院!杭州，310031，中国医学科学院浙江分院!杭州，310031，中国医学科学院浙江分院!杭州，310031 |
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| 摘 要： | 以睾酮为模型药物，研究介质对药物经皮渗透的影响，测定了睾酮在不同介质中的溶解度及睾酮在这些介质中通过大鼠皮肤的渗透速率。经Hildebrand法计算得到药物和介质的溶解度参数。结果显示，睾酮的经皮渗透系数的对数（logp）与介质的溶解度参数［δv(n)］之间呈倒置抛物线相关，当介质的溶解度参数接近药物溶解度参数时药物的渗透系数达最小值。
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| 关 键 词： | 睾酮 经皮渗透 溶解度参数 渗透系数 |
The Relationship of the Permeability Coefficients of Testosterone with Solubility Parameters of Vehicles |
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| Hu Fuqiang, Liang Wenquan, Shong Jifen, Wu Qiufan.The Relationship of the Permeability Coefficients of Testosterone with Solubility Parameters of Vehicles[J].Acta Academiae Medicinae Sinicae,1997,19(2):127-130. |
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| Authors: | Hu Fuqiang Liang Wenquan Shong Jifen Wu Qiufan |
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| Institution: | Zhejiang Branch, CAMS, Hangzhou. |
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| Abstract: | The effects of vehicles on the penetration through rat skin of testosterone were investigated. The solubilities of testosterone in various vehicles and the fluxes through rat abdomen skin had been determined. The solubility parameters of testosterone (delta i) and vehicles (delta v(n)) were calculated by Hildebrand's method. There was a good inverse parabola correlation between the log permeability coefficients (logp) and (delta v(n)). When delta v(n) approched delta i the permeability coefficients of testosterone approched the minimum as its limit. |
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| Keywords: | testosterone percutaneous penetration solubility parameters permeability coefficients |
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