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| LC-MS-MS法分析伏立康唑的碱降解产物 | |
| 引用本文： | 谢社平,廖琼峰,谢智勇. LC-MS-MS法分析伏立康唑的碱降解产物[J]. 中国药房, 2008, 19(13): 1007-1009 |
| 作者姓名： | 谢社平 廖琼峰 谢智勇 |
| 作者单位： | 1. 湖南永兴县人民医院药剂科,永兴县,423300 2. 广州中医药大学中药学院中药分析教研室,广州市,510006 3. 中山大学药学院药物分析与质量评价实验室,广州市,510080 |
| 摘 要： | 目的:建立以液相色谱-串联质谱法快速分析伏立康唑的碱降解产物的方法。方法:借助色谱-串联质谱技术,比较并分析伏立康唑对照品和其碱降解产物的相对分子质量、碎片、光谱特征等信息。结果:伏立康唑与其降解产物能有效分离,2个主要降解产物分别为去4-乙基-5-氟嘧啶的同分异构体。结论:该方法快速、灵敏、专属性强,可用于推测伏立康唑降解产物的结构。 |
| 关 键 词： | 伏立康唑 液相色谱-串联质谱法 降解产物 |
| 文章编号： | 1001-0408(2008)13-1007-03 |
| 修稿时间： | 2007-09-29 |
Identification of the Alkali Degradation Compounds of Voriconazole by LC-MS-MS |
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| XIE She-ping,LIAO Qiong-feng,XIE Zhi-yong. Identification of the Alkali Degradation Compounds of Voriconazole by LC-MS-MS[J]. China Pharmacy, 2008, 19(13): 1007-1009 | |
| Authors: | XIE She-ping LIAO Qiong-feng XIE Zhi-yong |
| Affiliation: | XIE She-ping,LIAO Qiong-feng,XIE Zhi-yong(1.Dept. of Pharmacy, Hu＇nan Yongxing County People＇s Hospital, Yongxing 423300, China;2.Dept. of Chinese Materia Medica Analysis, College of Chinese Traditional Medicine, Guangzhou University of TCM, Guangzhou 510006, China;3.Laboratory of Pharmaceutical Analysis ＆ Quality Assessment, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510080, China) |
| Abstract: | OBJECTIVE： To establish an LC - MS - MS method for the rapid analysis of the degradation compounds of vorionazole. METHODS： The degradation compounds and the control substance of vorionazole were compared in respect of relative molecular mass, fragments, spectra characteristics using LC- MS- MS technology. RESULTS： Vorionazole and its degradation compounds could be effectively isolated. The two main degradation compounds were the isomers of 4-ethyl- 5- fluoropyrimidine. CONCLUSION： The analytic method is rapid, sensitive, and specific, and it can be applied to predicate the structure of the degradation compounds of vorionazole. |
| Keywords: | Vorionazole LC - MS - MS Degradation compounds |
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