血液灌流联合血浆置换治疗重型肝炎632例

目的：评价血液灌流联合血浆置换治疗重型肝炎的临床疗效。方法：收集632例重型肝炎患者,其中慢性肝功能衰竭211例,慢性肝功能衰竭115例,急性肝功能衰竭306例,均采用血液灌流联合血浆置换治疗,观察治疗前后临床症状、肝功能、电解质、凝血酶原活动度（PTA）、血氨等指标变化。结果：患者临床症状均得到不同程度改善,治疗前后比较黄疸指数、转氨酶、凝血酶原活动度均有显著差异（P〈0.05）;治愈率为72.97%;不良反应较轻。结论：血液灌流联合血浆置换是治疗重型肝炎的一种较为安全、有效的方法。

Treatment for 632 Patients with Fulminant Hepatitis by Blood Perfusion and Plasmapheresis

Objective：To assess curative effects of blood perfusion and plasmapheresis in treagting fulminant hepatitis. Methods：All 632 patients were collected, among them, there were 211 ones with chronic liver failure, 115 ones with acute-on-chronic liver failure and 306 patients with acute liver failure, and they were treated by blood per-fusion and plasmapheresis, the changes of clinical symptom, liver function, electrolytes, prothrombin time activity （PTA）, blood ammonia and others were observed before and after treating. Results：Clinical symptoms of the patients were improved in different degrees, and there were significant differences between before and after treating in icteric index, aminopherase and PTA （P〈0.05）;cure rate was 72.97%;adverse reaction was slighter. Conclusion：Blood perfusion and plasmapheresis are one method for fulminant hepatitis which is safe and effective.