地屈孕酮在冻融胚胎移植激素替代周期中的应用 |
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引用本文: | 黄春,陈自洪,周莉,王书佳,朱小凤.地屈孕酮在冻融胚胎移植激素替代周期中的应用[J].中国航天医药杂志,2014(3):29-31. |
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作者姓名: | 黄春 陈自洪 周莉 王书佳 朱小凤 |
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作者单位: | 广西壮族自治区人口和计划生育研究中心生殖医学科, 广西南宁530021 |
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摘 要: | 目的:比较口服地屈孕酮与肌肉注射黄体酮应用于冻融胚胎移植(FET)激素替代黄体支持的临床效果。方法回顾性分析在本中心接受激素替代(HRT)内膜准备方案行FET治疗周期患者的临床资料。月经第3日起口服雌二醇片2mg,第14日超声监测。内膜≥8mm时,加用口服地屈孕酮60mg转化内膜(A组),或肌注油剂黄体酮80mg(B 组),5d后解冻第5d 胚胎。结果共完成689个 FET 激素替代周期, A、B 两组临床妊娠率分别为42%、35%,种植率分别为27.3%、24.1%,流产率分别为20.1%、15.7%,组间比较差异均无统计学意义(P>0.05)。结论 FET 激素替代周期中口服地屈孕酮简单方便,临床结果理想,可以替代肌肉注射油剂黄体酮。
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关 键 词: | 冻融胚胎 激素替代周期 地屈孕酮 黄体酮针 |
Application of Dydrogesterone in the hormone replacement cycles for frozen-thawed embryo transfer |
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Abstract: | Objective To compare the clinical effects of oral dydrogesterone and intramuscular progesterone in hormone replaced treatment of frozen-thawed embryo transfer(FET). Methods The clinical data of patients in our center was taken for a retrospective analysis. Since the third day of menstruation , 2mg estradiol was administered orally. Ultrasound scan was per-formed at the fourteenth day of menstruation. When the thickness of endometrium was greater than 8mm , oral dydrogesterone 60mg (group A) or intramuscular progesterone 80mg (group B) was administered. All the fifth day embryos were thawed 5 days later. Results Totally 689 hormone replacement cycles were performed. The clinical pregnancy rates in the group A and group B were 42%and 35%, the implantation rates were 27.3%and 24.1%, and the abortion rates were 20.1%and 15.7%respective-ly. There was no significant difference in the two groups (P>0.05). Conclusion The clinical result is perfect in oral dydro-gesterone in FET hormone replaced treatment, which suggests it can replace intramuscular progesterone completely in the treat-ments. |
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Keywords: | Frozen-thawed embryo Hormone replace treatment Dydrogesterone Progesterone |
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