参麦注射液与酚妥拉明治疗冠心病115例

目的：观察参麦注射液与酚妥拉明治疗冠心病的疗效。方法：将230例患者随机分为治疗组和对照组各115例。2组均给予吸氧、洋地黄、利尿、血管紧张素转移酶抑制剂等一般治疗。对照组在此基础上用5%葡萄糖注射液250 mL＋酚妥拉明注射液15 mg,1次/d,静脉滴注。治疗组在对照组的基础用5%葡萄糖注射液250mL＋参麦注射液80mL,静脉滴注,1次/d。2组均连续治疗2周。观察2组治疗前后血液流变学变化、临床疗效。结果：治疗组显效45例（39.13%）,有效59例（51.30%）,无效11例（9.57%）,总有效率90.43%;对照组显效32例（27.83%）,有效61例（53.04）,无效22例（19.13%）,总有效率80.87%。显效率、总有效率2组比较差异显著（P〈0.05）。全血高切黏度、全血中切黏度、全血低切黏度、血浆黏度2组治疗后与治疗前比较,差异显著（P〈0.05）;治疗后组间比较差异显著（P〈0.05）。结论：参麦注射液与酚妥拉明治疗冠心病临床疗效好,心功能改善明显。

ShenMai Injection and Phentolamine in Treating 115 Cases of Coronary Heart Disease

Objective：To survey curative effects of ShenMai injection and phentolamine in treating coronary heart disease. Methods：All 230 patients were randomly divided into the treatment group and the control group, 115 cases each group. Both groups were administered with general treatment including oxygen uptake, YangDiHuang （Digitalis）, diuretic, angiotensin converting enzyme inhibitor （ACEI） and others. The control group accepted intra-venous dripping of 5%blood glucose injection, 250 mL, and phentolamine injection, 15mL, once per day. The treat-ment group intravenous dripping of 5%blood glucose injection, 250mL, and ShenMai injection, 80mL, once per day. Both groups were treated for two consecutive weeks. Adverse reaction, clinical effects, clinical symptoms, the changes of heart function and hemorheology in both groups were observed before and after treating. Results：There were 45 cases markedly effective （39.13%）, 59 cases effective （51.30%）, 11 cases ineffective （9.57%） and total ef-fective rate of the treatment group was 90.43%;there were 32 cases markedly effective （27.83%）, 61 cases effective （53.08%）, 22 cases ineffective （19.13%） and total effective rate of the control group was 80.87%. The difference was significant in markedly effective rate and total effective rate between both groups （P〈0.05）. The difference was no-table in whole blood high shear viscosity, whole blood moderate shear viscosity, whole blood low shear viscosity and plasma viscosity of both groups between before and after treating （P〈0.05）;the difference was notable between both groups after treating （P〈0.05）. Conclusion：ShenMai injection and phentolamine could obtain better effects in treating coronary heart disease and improve of heart function notably.