| 镍及镍化合物对叙利亚地鼠胚胎细胞克隆转化及转化灶系统作用的研究 |
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| 引用本文： | 唐平,徐刚,陈晓禾,王艳萍,张文庚,袁淑兰. 镍及镍化合物对叙利亚地鼠胚胎细胞克隆转化及转化灶系统作用的研究[J]. 四川大学学报(医学版), 1988, 0(2) |
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| 作者姓名： | 唐平 徐刚 陈晓禾 王艳萍 张文庚 袁淑兰 |
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| 作者单位： | 华西医大肿瘤研究所(唐平，徐刚，陈晓禾，王艳萍，张文庚)，华西医大肿瘤研究所(袁淑兰) |
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| 摘 要： | 作者用从某厂采集的金属镍粉、硫化镍矿粉及氯化镍,对叙利亚地鼠胚胎细胞进行克隆转化系统和转化灶系统的转化作用的研究,发现上述三种镍或镍化合物均能诱发一个或两个转化系统的形态学转化。其转化率与3-甲基胆蒽阳性对照组的转化率近似甚至略高。
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| 关 键 词： | 镍 镍化合物 叙利亚地鼠细胞 形态转化作用 致癌作用 |
STUDIES OF THE EFFECT OF NICKEL AND NICKEL COMPOUNDS ON TRANSFORMATION ON SYRIAN HAMSTER EMBRYO CELLS |
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| Tang Ping,Xu Gang,Chen Xiaohe,Wang Yanping Zhang Wengeng,Yuan Shulan Institute of Cancer Research. STUDIES OF THE EFFECT OF NICKEL AND NICKEL COMPOUNDS ON TRANSFORMATION ON SYRIAN HAMSTER EMBRYO CELLS[J]. Journal of Sichuan University. Medical science edition, 1988, 0(2) |
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| Authors: | Tang Ping Xu Gang Chen Xiaohe Wang Yanping Zhang Wengeng Yuan Shulan Institute of Cancer Research |
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| Affiliation: | Tang Ping;Xu Gang;Chen Xiaohe;Wang Yanping Zhang Wengeng;Yuan Shulan Institute of Cancer Research |
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| Abstract: | This paper reports the studies of the ef-fect of nickel powder, nickel sulfide ore andnickel chloride on transformation in clonalsystem or focus system of Syrian hamsterembryo cells. The results showed that thenickel or nickel compounds could producemorphological transformations in one orboth transforming systems. Their transfo-rming efficiencies are as high as that of3-MCA or even higher. |
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| Keywords: | Nickel Nickel compounds Syrian hamster embryo cells Morphological transformation Carcinogenesis |
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