| 瓜石汤对初老大鼠卵巢Bcl-2表达影响的实验研究 |
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| 引用本文： | 郑君,李琪,孙凤平,吴克明. 瓜石汤对初老大鼠卵巢Bcl-2表达影响的实验研究[J]. 成都中医药大学学报, 2012, 35(2): 43-44 |
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| 作者姓名： | 郑君 李琪 孙凤平 吴克明 |
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| 作者单位： | 1.甘肃省中医院,甘肃兰州,730050;2.河南省南阳市宛城区河南油田职工总医院,473400;3.成都中医药大学,四川成都,610075 |
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| 基金项目： | 成都中医药大学2009年度博士创新基金 |
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| 摘 要： | 目的:探讨瓜石汤延缓初老雌性大鼠卵巢机能衰老的机理.方法:选10～12月龄、阴道细胞学涂片显示动情周期长、动情周期紊乱者作为初老大鼠模型随机分组,灌药4周后处死,取同侧卵巢用于检测Bcl-2.结果:与模型组比较,瓜石汤组Bcl-2的表达均有所增强,其中瓜高组与模型组比较有统计学意义(P＜0.05).结论:瓜石汤具有抑制卵巢细胞凋亡的作用,这可能是其延缓卵巢机能衰老的机理之一.
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| 关 键 词： | 瓜石汤 初老雌性大鼠 卵巢 Bcl-2 |
Experimental Study on Infiuence of Gua-shi Decoction to Bcl-2 Expression of Primary Senile Rat Ovary |
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| Affiliation: | ZHENG Jun1,LI Qi2,SUN Feng-ping1,et al(1.Gansu Hospital of Traditional Chinese Medicine,Lanzhou,730050,China;2.General Hospital of Henan Oil Field,Nanyang,473400,China) |
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| Abstract: | Objective:To discuss the mechanism of Gua-shi Decoction to delay the age of the primary senile rat ovary.Methods:10~12 months old SD female rats whose oestrus elongation were set as primary senile female rat model.Primary senile rats were devided randomly.After 4 weeks,weighed and sacrificed the rats.The ovaries were treated to observe expression of Bcl-2.Results:GuaShiTang could increase the expression of Bcl-2,compared with the model group,the high dose Gua-shi Decoction group have significant difference(P<0.05).Conclusion:Gua-shi decoction could restrain ovary apoptosis.The effect may be one of the mechanism of Gua-shi Decoction delay the aging of primary senile rat ovary. |
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| Keywords: | Gua-shi Decoction primary senile female rat ovary Bcl-2 |
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