| B类清道夫受体CD36的研究进展 |
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| 引用本文： | 高磊,鲍羿,洪斌. B类清道夫受体CD36的研究进展[J]. 医学分子生物学杂志, 2006, 3(1): 61-64 |
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| 作者姓名： | 高磊 鲍羿 洪斌 |
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| 作者单位： | 中国医学科学院,中国协和医科大学,医药生物技术研究所,北京市,100050;中国医学科学院,中国协和医科大学,医药生物技术研究所,北京市,100050;中国医学科学院,中国协和医科大学,医药生物技术研究所,北京市,100050 |
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| 摘 要： | CD36是一种跨膜糖蛋白,可与多种配基相结合,它在体内的分布广泛。作为一种清道夫受体,CD36既参与脂质的代谢,也在带负电荷的生物大分子黏附中发挥作用。对CD36的调控可能是巨噬细胞泡沫化和动脉粥样硬化形成的关键因素。迄今还发现其与肿瘤、肥胖等多种问题相关,一些CD36相关的药物研究也在进行中。
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| 关 键 词： | 跨膜糖蛋白 过氧化物酶体增殖物激活受体 动脉粥样硬化 长链脂肪酸 |
| 修稿时间： | 2005-05-18 |
Advances in Class B Scavenger Receptor CD36 |
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| GAO Lei,BAO Yi,HONG Bin. Advances in Class B Scavenger Receptor CD36[J]. Journal of Medical Molecular Biology, 2006, 3(1): 61-64 |
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| Authors: | GAO Lei BAO Yi HONG Bin |
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| Abstract: | CD36 is a transmembrane glycoprotein and can combine with a variety of ligands. It is extensively found in many tissues. As a scavenger receptor, CD36 is not only involved in the metabolism of lipids, but also plays a role in the adhesion of negatively-charged macromolecules. The regulation of CD36 may serve as a key determinant in the formation of macrophage foam cells and atherosclerosis. CD36 is also associated with tumorigenesis, obesity and some other diseases. Researches on the drugs related to the receptor are now under way. |
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| Keywords: | glycoprotein peroxisome proliferator activated receptor atherosclerosis long chain fatty acid |
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