| 黑素瘤相关通路及治疗的新进展 |
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| 引用本文： | 熊慧姊,许辉,陈文娟,史玉玲.黑素瘤相关通路及治疗的新进展[J].国际皮肤性病学杂志,2016(3):195-198. |
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| 作者姓名： | 熊慧姊 许辉 陈文娟 史玉玲 |
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| 作者单位： | 1. 200072上海,同济大学附属第十人民医院皮肤科;苏州大学;2. 同济大学附属第十人民医院皮肤科,上海,200072 |
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| 基金项目： | 国家自然科学基金(81301356)，上海市自然科学基金(13ZR1432200)，上海市科学技术委员会科研计划引导项目(134119b0700)National Natural Science Foundation of China(81301356)，Shanghai Municipal Natural Science Foundation(13ZR1432200)，Planning Program for Scientific Research of Shanghai Science and Technology Committee(134119b0700) |
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| 摘 要： | 黑素瘤的发病机制与遗传、环境因素如紫外线长期照射有关.研究表明,黑素瘤的发生发展主要与细胞外调节蛋白激酶通路和磷酸酰肌醇3激酶/蛋白激酶/哺乳动物雷帕霉素靶蛋白信号通路改变相关.相关的基因改变有:BRAF基因、NRAS基因、GNAQ基因和GNA 11基因、C-kit基因、苏氨酸蛋白激酶基因等.黑素瘤是皮肤侵袭性肿瘤,对于放疗和化疗均不敏感.针对黑素瘤发病机制的分子靶向治疗发挥了重要的作用,包括免疫治疗、基因治疗以及针对肿瘤血供的治疗.生物治疗比传统治疗有更好的靶向性和特异性.
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| 关 键 词： | 黑色素瘤 蛋白激酶类 信号传导 分子靶向治疗 |
Melanoma-related signaling pathways and its therapy |
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| Abstract: | The pathogenesis of melanoma is related to genetic and environmental factors such as longterm exposure to ultraviolet rays.Recent studies have shown that the occurrence and development of melanoma are mainly associated with changes in the extracellular signal-regulated protein kinase (ERK) pathway and phosphatidylinositol 3-kinase (PI3K)/serine/threonine kinase (AKT)/mammalian target of rapamycin (mTOR) pathway,as well as changes in genes BRAF,NRAS,GNAQ,GNA11,C-kit,AKT,etc.Melanoma is an invasive cutaneous tumor,and usually resistant to chemotherapy and radiotherapy.Molecular therapy targeting the pathogenesis of melanoma plays very important roles in the treatment of melanoma,including immunotherapy,gene therapy and tumor blood supply-targeted therapy.Biological therapy has shown higher targeting ability and specificity than conventional therapy. |
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| Keywords: | Melanoma Protein kinases Signal transduction Molecular targeted therapy |
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