| miRNA靶向RAS-MAPK通路的表观遗传性激活与肿瘤 |
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| 引用本文： | 丁苗.miRNA靶向RAS-MAPK通路的表观遗传性激活与肿瘤[J].国际病理科学与临床杂志,2016(11):1868-1872. |
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| 作者姓名： | 丁苗 |
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| 作者单位： | 1. 江西中医药大学2014级中西医结合临床专业,南昌,330004;2. 南昌市第三医院内分泌代谢科,南昌,330009 |
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| 基金项目： | 国家自然科学基金(81260133)；上海市糖尿病重点实验室开放课题资助项目(SHKLD-KF-1302)。This work was supported by the National Natural Science Foundation of China(81260133)，Open Research @@@@of Shanghai Key Laboratory of Diabetes Melitus(SHKLD-KF-1302)，P. R. China |
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| 摘 要： | 肿瘤作为一种难治性疾病，全世界都在为其治疗寻找新靶点。高度保守的RAS-MAPK通路在生物界大多数细胞内都广泛存在，主要通过各种级联反应刺激来控制细胞增殖分化等功能。体细胞基因突变编码RAS-MAPK通路经常发生在许多肿瘤中。miRNAs作为近年来研究较多的一种基因表达调控方式，其是通过与相关靶基因3’-UTR区结合来降解mRNA或抑制翻译表达。明确miRNA调控RAS-MAPK在肿瘤发生发展中的机制，可能为肿瘤的治疗提供新靶点。
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| 关 键 词： | RAS-MAPK信号通路 miRNAs 肿瘤 |
Epigenetic activation the miRNAs target the RAS-MAPK pathway and cancer |
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| Abstract: | As a refractory disease, people all over the world are looking for new targets for the treatment of tumor. The highly conserved ARS-MAPK pathway is involved in a wide range of cellular processes. It works with a variety of cascading reaction to control cell proliferation differentiation and other functions. Somatic genes mutations encoding the ARS-MAPK pathway otfen occur in many tumors. MicroRNAs are researched as a way of regulating the genic expression in recent years, and they degrade the mRNA or inhibit the translation by targeting the gene 3'-UTR region. Understanding the mechanism of how miRNA regulates the ARS-MAPK in the development of tumor may provide new targets for the treatment of tumor. |
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| Keywords: | ARS-MAPK pathway microRNAs cancer |
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