抗癫痫药物对热性惊厥相关癫痫患者发作控制的效果观察

目的：探讨抗癫痫药物(antiepileptic drugs，AEDs)对热性惊厥相关癫痫患者发作控制的效果。方法：选取2012年1月至2015年2月在我院治疗的热性惊厥相关癫痫患者190例，比较不同AEDs对热性惊厥相关癫痫患者发作控制的效果。结果：190例患者中共使用AEDs药物5种，分别为：丙戊酸、托吡酯、氯硝安定、苯巴比妥、左乙拉西坦。使用比例前三位的AEDs为丙戊酸、托吡酯、氯硝安定，比例分别为87.20%、64.47%和43.50%；190例患者中联合用药107例，占56.32%，单药治疗83例，占43.68%；单药治疗和联合用药对发作控制效果比较无统计学意义(P>0.05)；丙戊酸、托吡酯和氯硝安定对发作改善的效果最好，明显好于苯巴比妥和左乙拉西坦，而苯巴比妥和左乙拉西坦对发作改善的效果比较差异无统计学意义(P>0.05)。结论：热性惊厥相关癫痫患者治疗应首选丙戊酸、托吡酯和氯硝安定，三种药物控制效果较好，值得临床推广使用。

Observation of the control effect of antiepileptic drugs on febrile convulsion related epilepsy

Objective:To investigate control effect of anti-epileptic seizures drugs on febrile convulsion related epilepsy. Methods:Selected from January 2013 to February 2015 in our hospital 190 cases febrile convulsion related epilepsy, compared different AEDs on febrile convulsion related epilepsy control effect.Results: A total of 190 patients used five kinds AEDs drugs, including valproate, topiramate, clonazepam, phenobarbital, levetiracetam; the top three proportion AEDs were topiramate, valproate and clonazepam, respectively 87.20%, 64.47% and 43.50%; 117 of 190 patients in the combination therapy, accounting for 86.05%, monotherapy 12 cases, accounting for 13.95%; monotherapy and combination therapy for seizure control results were not statistically signiifcant (P>0.05); valproate, topiramate and clonazepam on seizures improvement had best effect, significantly better than phenobarbital and levetiracetam, while phenobarbital and levetiracetam on the seizures improvement effect showed no statistically significant (P>0.05).Conclusion: Febrile convulsion related epilepsy treatment should be preferred valproate, topiramate and clonazepam, three kind of drugs control effect is good, it is worthy of clinical use.