Toll样受体2与缺血性脑白质损害

Toll样受体2(Toll-like receptor 2,TLR2)是Toll样受体家族中表达范围最广的受体,也是固有免疫系统对病原微生物的重要模式识别受体.另外,TLR2还可识别内源性危险信号,参与缺血性损伤等非病原微生物性炎性反应.有关TLR2及其信号转导在缺血性脑白质损害中的作用日益受到关注,文章对TLR2与缺血性脑白质病变的关系进行了综述.

Toll-like receptor 2 and ischemic cerebral white matter lesion

Toll-like receptor 2 (TLR2) is the most w idely expressed receptor in the Toll-like receptor family, and is also an important pattern recognition receptor of the innate immune system to pathogenic microorganisms. In addition, TLR2 can also identify endogenous risk signals and participate in non -pathogenic microbial inflammatory reaction in ischemic injury. The role of TLR2 and its signal transduction in ischemic cerebral w hite matter lesions have received more and more attention. This article reviews the relationship between TLR2 and ischemic cerebral white matter lesion.