| 肠促胰素类降糖药物对体重的作用 |
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| 引用本文： | 周欢欢,徐书杭,刘超,楼青青. 肠促胰素类降糖药物对体重的作用[J]. 国际内分泌代谢杂志, 2016, 0(3): 172-175. DOI: 10.3760/cma.j.issn.1673-4157.2016.03.007 |
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| 作者姓名： | 周欢欢 徐书杭 刘超 楼青青 |
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| 作者单位： | 1. 210023,南京中医药大学护理学院;2. 南京中医药大学附属中西医结合医院内分泌代谢病院区, 江苏省中医药研究院,210028;3. 南京中医药大学附属中西医结合医院健康教育科, 江苏省中医药研究院,210028 |
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| 摘 要： | 胰高血糖素样肽-1(GLP-1)受体激动剂和二肽基肽酶-4(DPP-4)抑制剂是新型的2型糖尿病治疗药物.普遍认为,GLP-1受体激动剂可显著减轻患者体重,DPP-4抑制剂对体重的作用为中性.然而,这两类药物与不同药物联用,患者体重可不同程度增加,尤其是与磺脲类或噻唑烷二酮类药物联用时.临床医师应了解GLP-1受体激动剂和DPP-4抑制剂对体重的影响,为2型糖尿病患者制定更合理、安全和有效的治疗方案.
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| 关 键 词： | 2型糖尿病 胰高血糖素样肽-1受体激动剂 二肽基肽酶-4抑制剂 体重 |
Effects of incretin drugs on body weight |
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| Abstract: | Incretins including glucagon-like peptide-1 (GLP-1) receptor agonists and dipeptidyl peptidase IV (DPP-4) inhibitors are a new type of anti-hyperglycemic drugs.Generally speaking,GLP-1 analogues are associated with significant weight loss,and DPP-4 inhibitors have a neutral effect on body weight.However,they still cause weight gain,particularly when combined with sulfonylureas or thiazolidinedione.Clinicians should be aware of the influence on body weight of GLP-1 analogues and DPP-4 inhibitors,which can lay the foundation for developing more rational,safe and effective treatments for patients with type 2 diabetes. |
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| Keywords: | Type 2 diabetes mellitus Glucagon-like peptide 1 receptor agonists Dipepidyl peptidase 4 inhibitors Body weight |
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