146例套细胞淋巴瘤免疫组织化学结果分析 |
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引用本文: | 李晶,胡昌明,丁向东,冯晓冬,任玉霞,朱梅刚.146例套细胞淋巴瘤免疫组织化学结果分析[J].国际病理科学与临床杂志,2016(6):733-736. |
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作者姓名: | 李晶 胡昌明 丁向东 冯晓冬 任玉霞 朱梅刚 |
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作者单位: | 1. 广州金域医学检验中心有限公司实验诊断部组织病理科,广州,510330;2. 广州金域医学检验中心有限公司实验诊断部分子病理科,广州,510330 |
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摘 要: | 目的:讨论套细胞淋巴瘤的免疫组织化学特征。方法:回顾性分析146例套细胞淋巴瘤的免疫组化结果,并用FISH方法检测1例Cyclin D1阴性病例是否存在t(11;14)易位。结果:套细胞淋巴瘤免疫组化阳性率为CD20:98.6%(144/146);CD79a:100%(146/146);CD5:88.4%(129/146);CyclinD1:99.3%(145/146);PAX-5:100%(122/122);CD43:84%(79/94);Ki67指数:5%~90%,中位数为20%。少部分病例异常表达CD10、Bcl6、CD23、CD56、CD3、CD45RO。FISH检测1例Cyclin D1阴性病例结果为检测到t(11;14)易位形成的IgH/CCND1融合基因。结论:套细胞淋巴瘤存在较为特征性的免疫组化表达模式,并存在异常表达现象。
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关 键 词: | 套细胞淋巴瘤 免疫组织化学 原位杂交 |
Immunohistochemical analysis of 146 cases of mantle cell lymphoma |
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Abstract: | Objective: To discuss the immunohistochemical features of mantle cell lymphoma (MCL).Methods: A retrospective analysis of immunohistochemical results of 146 cases of mantle cell lymphoma was performed, one cyclin D1 negative case was detected t(11;14) translocation with FISH.Results:hTe positive rate in 146 cases were CD20: 98.6%; CD79a: 100%; CD5: 88.4%; Cyclin D1: 99.3%; PAX-5: 100%; CD43: 84%; Ki67 index: 5%~90%. CD10, Bcl6, CD23, CD56, CD3 and CD45RO were positive in rare case. IgH/CCND1 fusion gene was substantiated in one cyclin D1 negative case.Conclusion:hTere is the characteristic expression pattern of immunohistochemistry in mantle cell lymphoma, and the abnormal expression existed. |
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Keywords: | mantle cell lymphoma (MCL) immunohistochemistry in situ hybridization |
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