| 高迁移率族蛋白-1与脑出血 |
| |
| 引用本文： | 李丽敏,赵迎春. 高迁移率族蛋白-1与脑出血[J]. 国际脑血管病杂志, 2016, 0(6): 565-568. DOI: 10.3760/cma.j.issn.1673-4165.2016.06.015 |
| |
| 作者姓名： | 李丽敏 赵迎春 |
| |
| 作者单位： | 201699,南京医科大学附属上海松江中心医院神经内科 |
| |
| 基金项目： | 上海市卫计委课题(201540141)Project of Shanghai Municipal Health and Family Planning Commission |
| |
| 摘 要： | 高迁移率族蛋白(high mobility group box 1,HMGB1)是一种广泛分布于真核细胞中高度保守的非组DNA结合蛋白.它是一种重要的促炎性细胞因子,参与多种病理生理学过程,例如炎症和神经血管生成等.在脑出血早期,HMGB1可诱发炎性反应、神经元坏死、脑水肿等继发性脑损伤;在脑出血晚期,HMGB1可促进血管神经发生,进而改善神经功能.将来,HMGB1有可能成为脑出血的新治疗靶点.
|
| 关 键 词： | 脑出血 HMGB1蛋白 炎症 |
High mobility group box 1 protein and intracerebral hemorrhage |
| |
| Abstract: | High mobility group box l protein (HMGB1) is a highly conserved non-histone DNA binding protein,which is widely distributed in eukaryotic cells.HMGB1 is an important proinflammatory cytokine,involving in various pathological and physiological processes,such as inflammation,neurogenesis and angiogenesis.In the early stage of intracerebral hemorrhage,HMGB1 can induce secondary brain injury,such as inflammatory reaction,neuronal necrosis,and brain edema.However,in the late stage of intracerebral hemorrhage,HMGB1 can promote angiogenesis and neurogenesis,and thus improving neurological function.HMGB1 will become a novel therapeutic target for intracerebral hemorrhage in the future. |
| |
| Keywords: | Cerebral Hemorrhage HMGB1 Protein Inflammation |
| 本文献已被 万方数据 等数据库收录！ |
|
