硒蛋白S与糖尿病及大血管并发症

硒蛋白S为一种膜蛋白,其组织分布广泛,与炎性反应、氧化应激及内质网应激关系密切.研究发现,不同组织的硒蛋白S在糖尿病及其大血管并发症发生、发展中的作用不同.胰腺及血管中的硒蛋白S发挥抗氧化及抗内质网应激的保护效应,而肝脏、脂肪组织及骨骼肌中的硒蛋白S反而促进糖尿病及胰岛素抵抗的发生、发展.因此,全面地剖析硒蛋白S在各组织中的作用特点及机制,可为糖尿病及其大血管并发症提供新的防治策略.

Relationship between selenoprotein S,diabetes and its macrovascular complications

Selenoprotein S is identified as a transmembrane protein and expressed in numberous tissues.It is closely related to inflammatory response,oxidative stress and endoplasmic reticulum stress.Selenoprotein S in different tissues has been suggested to play different roles in the pathogenesis and progression of diabetes and its macrovascular complications.Selenoprotein S in pancreatic and vascular exerts anti-oxidative and anti-endoplasmic reticulum stress capacity,while selenoprotein S in liver,adipose tissue and skeletal muscle can promote the pathogenesis and progression of diabetes and insulin resistance.Thus,analyzing the function and mechanism of selenoprotein S in various tissues comprehensively can provide new strategies for the prevetion and treatment of diabetes and its macrovascular diseases.