人类白细胞抗原与银屑病相关性研究进展

关于银屑病遗传病因学的研究越来越多,人类白细胞抗原基因是其中之一.银屑病与人类白细胞抗原基因的相关性研究提示,银屑病的易感基因或保护基因可能位于人类白细胞抗原基因区内,也可能与人类白细胞抗原单倍型相连锁形成扩展单倍型,这种相关性在不同的种族、地域存在明显差异.目前在中国汉族人群中尚未进行银屑病大样本量人类白细胞抗原基因区域的遗传学研究,今后可以此作为研究方向,以探索中国人群银屑病与人类白细胞抗原基因区域的关联,揭示银屑病病因及发病机制、促进临床治疗,推动银屑病精准医疗的发展.

Association between human leukocyte antigens and psoriasis

More and more studies have been conducted on genetic etiology of psoriasis,such as human leukocyte antigen (HLA) genes.It has been suggested that susceptibility or protective genes for psoriasis may be located in the HLA region,or be linked to HLA haplotypes to form extended haplotypes.In addition,the association varies distinctly with races and regions.So far,there has been no large sample-sized studies on HLA genes in Han Chinese patients with psoriasis yet,which are expected be carried out in the future to explore the association between HLA genes and psoriasis in Chinese population,reveal its etiology and pathogenesis,facilitate its diagnosis and treatment,and to promote development of precision medicine for it.