| Nesfatin-1与肥胖的关系 |
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| 引用本文： | 高胜利,郭菲菲,徐珞,孙向荣. Nesfatin-1与肥胖的关系[J]. 国际内分泌代谢杂志, 2016, 0(6): 384-387. DOI: 10.3760/cma.j.issn.1673-4157.2016.06.06 |
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| 作者姓名： | 高胜利 郭菲菲 徐珞 孙向荣 |
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| 作者单位： | 266021,青岛大学基础医学院病理生理学教研室 |
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| 基金项目： | 国家自然科学基金青年项目(81500414)，山东省优秀中青年科学家科研奖励基金(BS2014YY009)National Natural Science Foundation of China(81500414)，Research Award Fund for Out-standing Middle-aged and Young Scientist of Shandong Province(BS2014YY009) |
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| 摘 要： | Nesfatin-1是一种新发现的摄食抑制性脑肠肽,在中枢神经系统和多个外周组织中均有表达.Nesfatin-1基因多态性或蛋白表达异常均可能引发摄食增多和肥胖.Nesfatin-1可直接作用于摄食相关神经元,减轻肥胖程度;也可通过影响催产素、神经肽Y等神经肽的表达和功能,间接发挥降低体重的作用.
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| 关 键 词： | Nesfatin-1 Nucleobindin 2 摄食抑制 神经肽 肥胖症 |
Relationship between nesfatin-1 and obesity |
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| Abstract: | Nesfatin-1 is a novel anorexigenic brain-gut peptide and expressed in central nerve system and multiple peripheral tissues.Polymorphism and abnormal protein expression of nesfatin-1 might lead to hyperphagia and obesity.Nesfatin-1 not only directly abates obesity by influencing feeding-related neurons,but also indirectly decreases body weight by affecting the expressions and functions of many neuropeptides,such as oxytocin,neuropeptide Y,and so on. |
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| Keywords: | Nesfatin-1 Nucleobindin 2 Feeding inhibition Neuropeptide Obesity |
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