2型糖尿病男性患者骨代谢指标与骨密度的相关性研究 |
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引用本文: | 袁心露,杨建军,朱静宜,杨培培,朱晓晖,崔世维.2型糖尿病男性患者骨代谢指标与骨密度的相关性研究[J].国际病理科学与临床杂志,2016(12):2022-2027. |
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作者姓名: | 袁心露 杨建军 朱静宜 杨培培 朱晓晖 崔世维 |
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作者单位: | 南通大学附属医院内分泌科,江苏 南通,226001 |
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基金项目: | 江苏省南通市科技项目课题(MS22015126)。This work was supported by Science and Technology Research Project Foundation of Nantong City |
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摘 要: | 目的:探讨2型糖尿病男性患者骨密度与骨代谢生化指标间的关系。方法:选取我科2014年1月至2015年12月入院的2型糖尿病男性患者102例,采用双能X线骨密度仪,测定腰椎(L2~L4)、股骨上端包括股骨颈(Neck)、华氏三角(Ward)及股骨粗隆(Troch)]和全身的骨密度(bone mineral density, BMD)值;根据T值将这些患者分为骨量正常组(44例)、骨量减少组(36例)和骨质疏松组(29例),采用酶联免疫法测定各组碱性磷酸酶(alkaline phosphatase,ALP)、N-端中段骨钙素(N-MID-OT)、总Ⅰ型胶原氨基端延长肽(type 1 amino-terminal propeptide,tP1NP)和β胶原特殊序列(β-CTX)的浓度,比较三组骨代谢指标的变化,并对BMD与各项骨代谢指标进行相关性分析。结果:随着骨密度的降低,骨代谢指标的水平逐渐增高,其中,N-MID-OT和β-CTX的水平在三组间的差异皆有统计学意义(P<0.05);tP1NP在骨质疏松组和其余两组有统计学差异(P<0.05);ALP在三组间无统计学差异(P>0.05)。骨量减少组中,N-MID-OT与Neck、Troch及全身的BMD呈负相关(r=?0.754,?0.663,?0.743;P<0.05),β-CTX与Ward的BMD呈负相关(r=?0.273;P<0.05);骨质疏松组中, N-MID-OT与所有部位的BMD呈负相关(r=?0.736,?0.562,?0.715,?0.521,?0.436;P<0.05),β-CTX与Neck、Ward及全身的BMD呈负相关(r=?0.532,?0.614,?0.764;P<0.05)。结论:2型糖尿病男性患者骨密度与骨代谢指标呈负相关,两者联合评估有助于早期预防骨质疏松。
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关 键 词: | 2型糖尿病 骨质疏松 骨代谢指标 骨密度 |
Investigation of the relationship between the bone turnover markers and bone mineral density in male type 2 diabetes patients |
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Abstract: | Objective:To assess the relationship between bone mineral density (BMD) and serum bone turnover markers (BTMs) in male type 2 diabetes mellitus (T2DM) patients.Methods: 102 T2DM men who were hospitalized from January 2014 to December 2015 were enrolled. BMD of the lumbar vertebrae (L2~L4), the proximal femur and the whole body was tested using dual X absorptiometry. All the subjects were divided into 3 groups according to T score. The concentrations of serum N-MID-OT, tP1NP, β-CTX and ALP were examined using ELISA method. hTe changes of BMD and BTMs among 3 groups were compared and the correlation between BMD and each BTMs was analyzed.Results: BMD of each location in the osteoporotic group was signiifcantly lower than that in the normal bone mass group (P<0.05). hTe concentrations of N-MID-OT, tP1NP and β-CTX in the osteoporotic group were significantly higher than those in the normal bone mass group (P<0.05). The concentration of N-MID-OT was negatively correlated with BMD of each location and that of β-CTX was negatively correlated with BMD of femoral neck, Troch and whole body in the osteoporotic group (P<0.05). Conclusion:BMD was negatively correlated with BTMs in male T2DM patients and the evaluation of both BMD and BTMs will make contributions to the prevention of osteoporosis at an early stage. |
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Keywords: | type 2 diabetes mellitus (T2DM) osteoporosis bone mineral density(BMD) serum bone turnover markers |
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