玉屏风颗粒联合常规对症治疗儿童反复呼吸道感染的meta分析

目的：评价玉屏风颗粒联合常规对症治疗对于儿童反复呼吸道感染的疗效。方法：计算机检索CNKI、VIP、WANFANG DATA、Sinomed以及PubMed、EMBASE、the Cochrane Library等，收集玉屏风颗粒对儿童反复呼吸道感染的疗效和免疫功能影响的随机对照研究，检索时限截止至2016年5月。由2位研究者按照纳入与排除标准筛选文献，提取数据和评价纳入研究的方法学质量后，采用RevMan 5.3软件进行meta分析。结果：共纳入18个研究，1845例患者。与对照组(常规对症治疗)相比，治疗组(常规对症治疗+玉屏风颗粒)在提升总有效率、抗体水平和T细胞水平上具有明显优势。结论：玉屏风颗粒联合常规对症治疗儿童反复呼吸道感染的总体疗效优于单纯常规对症治疗。但是由于文献的质量不高，仍需要大样本双盲随机试验的理论支持。

Meta-analysis of Yupingfeng granules combined with conventional symptomatic treatment on the treatment of children with recurrent respiratory tract infection

Objective:To evaluate the clinical efficacy of Yupingfeng granules combined with conventional symptomatic treatment for recurrent respiratory tract infection (RRTI). Methods:CNKI, VIP, WANFANG DATA, Sinomed, PubMed, EMBASE, the Cochrane Library was searched for the randomized controlled trials (RCTs) that investigated the clinical and immune effect of Yupingfeng granules in RRTI from inception to May 2016. The literature was screened according to the inclusion and exclusion criteria by 2 researchers. Extracted data and evaluated the methodological quality of included studies. Atfer the data were extracted, and the methodological quality of the included studies was evaluated, the meta-analysis was performed by the software RevMan 5.3. Results:A total of 18 studies involving 1 845 patients were included. hTe results of meta-analysis showed that compared with the control group (conventional symptomatic treatment), the experimental group (conventional symptomatic treatment+Yupingfeng granules) was superior in improving total effective rate, antibody level and Tcell level. Conclusion: Yupingfeng granules combined with conventional symptomatic treatment improves overall clinical efficacy in the treatment of RRTI. However, due to the low quality of the literatures, theoretical support of large sample double blind randomized trials is still needed.