2013-2015年鲍曼不动杆菌感染分布特征与耐药性变迁

目的：了解徐医附院2013—2015年临床分离鲍曼不动杆菌的临床分布特征及对抗菌药物的耐药性变迁，为临床合理使用抗菌药物提供依据。方法：对2013—2015年徐医大附院收集的所有鲍曼不动杆菌临床数据进行分析。结果：2013—2015年共收集鲍曼不动杆菌1664株，其中在临床ICU科室检出率最高，占58.2%。临床分离的鲍曼不动杆菌耐药严重，其中对碳青霉烯类抗菌药物的耐药率已高达73.0%以上。对其他β内酰胺类、头孢菌素类等抗菌药物的耐药率总体维持在70.0%~80.0%之间。结论：鲍曼不动杆菌感染在ICU最为严重，且对常规抗生素耐药率普遍较高。应加强鲍曼不动杆菌耐药监测，以提高临床对感染性疾病的诊治疗效。

Changes of antimicrobial agent resistance and distribution feature ofAcinetobacter baumannii during 2013-2015

Objective: To investigate the characteristics of clinical distribution and trend of drug resistance ofAcinetobacter baumannii isolated in the Affliated Hospital of Xuzhou Medical University from 2013 to 2015, and to provide the reference for clinical rational using of antimicrobial agents.Methods: All the data ofAcinetobacter baumannii isolated in the Affliated Hospital of Xuzhou Medical University between 2013 and 2015 were collected for statistical analysis.Results: A total of 1 664 isolates ofAcinetobacter baumannii were collected from 2013 to 2015, and the department of ICU provides the highest rate with 58.2%. hTe antibiotic resistance of clinical isolatedAcinetobacter baumannii was very serious, the drug-resistance rate of carbapenem reached up to over 73.0%. And the resistance rates of other lactam and cephalosporins were maintained at 70.0%~80.0%.Conclusion:The infection of Acinetobacter baumannii isolated from the ICU was the most serious. hTe clinical isolates are commonly resistant to all kinds of antimicrobial agents, monitoring the resistance ofAcinetobacter baumannii should be strengthened so as to improve the clinical treatment of infectious diseases.