| 梅毒免疫和梅毒螺旋体的研究进展 |
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| 引用本文： | 刘宏业,韩燕,尹跃平.梅毒免疫和梅毒螺旋体的研究进展[J].国际皮肤性病学杂志,2016(6):490-493. |
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| 作者姓名： | 刘宏业 韩燕 尹跃平 |
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| 作者单位： | 中国医学科学院北京协和医学院皮肤病研究所参比实验室,南京,210042 |
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| 摘 要： | 梅毒螺旋体有着独特的基因和蛋白结构,对其基因分型有利于梅毒分子流行病学的研究.梅毒螺旋体缺乏脂多糖与外膜蛋白,但可表达多种脂蛋白,这些脂蛋白同梅毒螺旋体的组织黏附及播散有关,同时可诱导机体发生免疫应答.机体对于梅毒螺旋体的免疫应答过程十分复杂,固有免疫、体液免疫及细胞免疫均在梅毒螺旋体的感染过程中参与了应答过程.Th1型细胞免疫在梅毒的发生发展过程中起重要作用,梅毒患者在局部及系统免疫方面都存在细胞免疫的异常.
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| 关 键 词： | 梅毒 苍白密螺旋体 免疫 抗原 Th1细胞 |
Immune response in syphilis and Treponema pallidum |
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| Abstract: | Treponema pallidum (Tp) has unique genome and protein structures.Tp genotyping may facilitate molecular epidemiological studies of syphilis.Tp lacks lipopolysaccharides and outer membrane proteins,but can express various lipoproteins,which are associated with tissue adhesion and dissemination of Tp,and can induce the host immune response.The host immune response to Tp is a very complex process with the involvement of innate immunity,humoral immunity and cellular immunity.T helper type 1 cell immunity plays an important role in the occurrence and development of syphilis.Both local and systemic cellular immunity are abnormal in patients with syphilis. |
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| Keywords: | Syphilis Treponema pallidum Immunity Antigens Th1 cells |
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