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电针对大鼠心胃两脏调节效应研究
引用本文:任彬彬,余芝,汪娅莉,徐斌.电针对大鼠心胃两脏调节效应研究[J].中国中西医结合杂志,2014,34(10):1212-1215.
作者姓名:任彬彬  余芝  汪娅莉  徐斌
作者单位:南京中医药大学针药结合省部共建教育部重点实验室(南京210023)
基金项目:国家重点基础研究发展计划(973计划)项目(No.2011CB505206);国家自然科学基金资助项目(No. 81202744,81373749);中国中医科学院自主选题项目(No.ZZKF06003);江苏省特色优势学科资助项目;江苏省高校“青蓝工程”优秀科技创新团队资助项目
摘    要:目的研究针刺大鼠同一腧穴对心和胃两个脏腑调节效应差异。方法 80只SD雄性大鼠随机分为内关组、曲池组、天枢组、膻中组、足三里组、三阴交组、心俞组、胃俞组,每组10只,观察电针(2/15 Hz,3mA,2 min)不同腧穴对胃运动(胃内压)和心功能(左室心内压)的调节效应,比较针刺前2 min和针刺2 min的均值。结果与本组电针前比较,内关、曲池、膻中、三阴交、心俞组左心室内压均降低(P〈0.05),曲池、足三里、三阴交、心俞组胃内压升高,天枢、膻中、胃俞组胃内压降低(P〈0.05)。各组针刺后心内压差值由高到低分别为:心俞〉膻中〉内关〉三阴交〉曲池,对胃内压差值由高到低分别为:天枢〉胃俞〉心俞〉膻中〉足三里〉三阴交〉曲池。结论运用电针(2/15 Hz,3 mA)刺激大鼠同一腧穴,对心和胃均调节作用,其效应方向和量,因腧穴所在部位、归经、支配神经节段或观察脏腑的不同而存在差异性,并针对单一脏器显示出相对固定的效应倾向。

关 键 词:电针  心内压  胃内压

Regulatory Effect of Electroacupuncture on Heart and Stomach of Rats
Authors:REN Bin-bin  YU Zhi  WANG Ya-li  XU Bin
Institution:(Key Laboratory of Integrated Acupuncture and Drugs Affiliated to the Minis- try of Education of the People' s Republic of China, Nanjing University of Chinese Medicine, Nanjing 210023, China)
Abstract:Objective To explore different regulatory effects of electroacupuncture (EA) at the same acupoint on the heart and the stomach. Methods Eighty male SD rats were randomly divided into eight groups equally, i.e., the Neiguan (PC6) group, the Quchi (Llll) group, the Tianshu (ST25) group, the Danzhong (RN17) group, the Zusanli ( ST36 ) group, the Sanyinjiao (SP6) group, the Xinshu (BL15) group, and the Weishu (BL21) group, 10 in each group. The regulatory effects of EA (2/15 Hz, 3 mA, 2 min) at different acupoints on the gastric motility (intragastric pressure) and the cardiac function (the left ventricular pressure) were observed. The mean values of effect of two-min pre-EA and after-EA were compared. Results Compared with the pre-EA in the same group, the left ventricular pressure decreased in the Neiguan (PC6) group, the Quchi (Llll) group, the Danzhong (RN17) group, the Sanyin-jiao (SP6) group, and the Xinshu (BL15) group (P 〈0.05). The intragastric pressure increased in the Quchi (Llll) group, the Zusanli (ST36) group, the Sanyinjiao (SP6) group, and the Xinshu (BL15) group, while it decreased in the Tianshu (ST25) group, the Danzhong (RN17) group, and the Weishu (BL21) group (P 〈0.05). The difference of the left ventricular pressure was sequenced from high to low as Xinshu (BL15) 〉Danzhong (RN17) 〉 Neiguan (PC6) 〉 Sanyinjiao (SP6) 〉 Quchi (Ll11). The differ- ence of the intragastric pressure was sequenced from high to low as Tianshu (ST25) 〉Weishu (BL21) 〉 Xinshu (BL15) 〉 Danzhong (RN17) 〉 Zusanli (ST36) 〉 Sanyinjiao (SP6) 〉 Quchi (Ll11). Conclusions EA at the same acupoint (2/15 Hz, 3 mA) showed different regulatory effects on the heart and stomach. There existed some difference in the direction and size due to the acupoint location, meridians, dominant nerve segment or relating organs. A fixed effect direction to the specific target
Keywords:electroacupuncture  intracardiac pressure  intragastric pressure
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