血清hs-CRP与TCH/HDL-C联合检测在冠心病中的应用

目的研究血清高敏C反应蛋白(hsCRP)、总胆固醇与高密度脂蛋白胆固醇之比(TCH/HDLC)与冠心病患者冠状动脉病变狭窄程度的相关性,探讨hsCRP、TCH/HDLC联合检测在冠心病中的应用价值。方法冠状动脉造影确诊的冠心病患者82例,其中稳定型心绞痛(SAP)组25例,不稳定型心绞痛(UAP)组27例,急性心肌梗死(AMI)组30例,对冠脉造影结果采用Gensini积分系统定量评定冠脉血管病变狭窄严重程度,以冠脉造影正常者(52例)为正常对照组,采用颗粒增强免疫透射比浊法测定血清hsCRP,采用酶法测定血清TCH、HDLC,分析血清hsCRP、TCH/HDLC联合检测对冠状动脉病变严重程度的预测价值。结果冠状动脉病变狭窄程度Gensini积分与hsCRP呈正相关(r=0.741,P<0.05),与TCH/HDLC亦呈正相关(r=0.542,P<0.05),而且随着冠状动脉病变程度加重,血清hsCRP、TCH/HDLC有明显升高,与对照组比较,有统计学意义(P<0.05),而SAP组与对照组相比,hsCRP、TCH/HDLC水平差异无统计学意义(P>0.05)。结论hsCRP、TCH/HDLC与冠心病患者冠状动脉病变程度密切相关,其联合检测有助于冠心病患者冠状动脉病变严重程度的临床评估。

Combined detection of hs-CRP and TCH/HDL-C in coronary heart disease

Objective To examine the relationship between serum high-sensitivity C-reactive protein (hs-CRP),the ratio of total cholesterol to HDL cholesterol (TCH/HDL-C) and the stenosis of coronary in patients with coronary heart disease(CHD).To investigate their combined detection value in the evaluation of the severity of CHD.Methods Eighty-two patients were diagnosed with CHD by coronary angiography,among which 25 cases were in the stable angina pectioris(SAP) group,27 cases were in the unstable angina pectoris (UAP) group,and the remaing 30 cases were in the acute myocardial infarction(AMI) group.The severity scale of coronary artery stenosis was quantitatively assessed according to coronary angiography by Gensini score.There were 52 normal controls,who underwent coronary angiography and proved to be free of CHD.The plasma hs-CRP level in CHD patients and control group was determined by particle enhanced immunoturbidinetric assay,the levels of TCH and HDL-C determined by method of enzyme.The combined detection of the levels hs-CRP and THC/HDL-C was analyzed to explore their predictive value in the severity evaluation of the stenosis of coronary artery. Results Gensini score of CHD stenosis correlated positively with both hs-CRP and TCH/HDL-C,and also correlated positively with severity of CHD.But there was no significant difference in the levels of hs-CRP and TCH/HDL-C between SAP group and control group(P>0.05).Conclusion hs-CRP and TCH/HDL-C are closely associated with the stenosis,their combined detection would also be helpful in the evaluation of the severity of coronary artery disease.