妊娠高血压综合征孕妇血小板及血液流变学指标的观察分析

目的:对妊娠高血压综合征孕妇血小板参数及血液流变学指标进行观察分析。方法:选择妊高征待产孕妇45例(妊高征组),正常妊娠待产孕妇45例(正常妊娠组),正常非妊娠期妇女45例(对照组)作为研究对象。测定3组妇女红细胞压积、红细胞数量、血红蛋白浓度、血小板参数、纤维蛋白原浓度、全血及血浆粘度。结果:(1)妊高征组血小板平均容积、血小板容积分布宽度和大血小板比率高于对照组及正常妊娠组(P<0.05);(2)妊高征组全血粘度及血浆粘度均高于正常妊娠组(P<0.05);正常妊娠组均高于对照组(P<0.05)。结论:妊高征孕妇血小板参数及血液流变学指标的变化较正常妊娠组及对照组有显著性意义,说明血小板活化及血液流变学改变参与了妊高征的发生、发展过程。

Variation of Platelets and Hemorheology Parameters in Pregnancy Induced Hypertension

Objective: To study the variation of platelets and hemorheology parameters in pregnancy induced hypertension (PIH).Method: Forty-five patients with PIH in third trimester and forty-five normal pregnant women in third trimester were included.Forty-five normal women without pregnancy served as controls.Blood platelets (PLT),Platelet distribution width (PDW),mean platelet volume (MPV),platelet-large cell ratio (P- LCR),RBC,HGB,Hct,Fib,blood viscosity and plasma viscosity were measured.Results: (1) The MPV,PDW,P-LCR in PIH were significantly higher than that in normal pregnant women and controls.(2) The blood viscosity and plasma viscosity in PIH were higher than that in normal pregnant women (P<0.05),and the same index of normal pregnant women were higher than that in controls (P<0.05).Conclusion: The parameters of platelet and hemorheology were higher in PIH than normal pregnant women and controls,it means the activity of platelet is enhanced and the hemorheology states were disturbed in PIH.The hemorheology and platelet may play an important role in the pathogenesis and development of PIH.